Hematologic and biochemical changes associated with human T lymphotropic virus type 1 infection in Jamaica: A report from the population-based blood donors study
Hematologic and biochemical changes associated with human T lymphotropic virus type 1 infection in Jamaica: A report from the population-based blood donors study
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DOI：
10.1086/521932
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发表时间：
2007-10-15
影响因子：
11.8
通讯作者：
Hisada, Michie
中科院分区：
文献类型：
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作者：
Chaturvedi, Anil K.;Wilson, Marianna;Hisada, Michie
目标。我们研究了血液学和生化参数的变化与人1型嗜T淋巴病毒（HTLV-1）感染、抗体滴度和原病毒载量相关。此外，在一部分参与者中，我们评估了HTLV-1与粪形圆线虫的流行病学关系。在牙买加的志愿献血者中，HTLV-1携带者（n = 482）与HTLV-1阴性受试者（n = 355）按年龄（+/-5岁）、性别和献血日期（+/-3个月）进行频率匹配。检测HTLV-1抗体滴度、原病毒载量、粪球菌IgG抗体、全血细胞计数、血液化学及尿液分析指标。与HTLV-1阴性个体相比，HTLV-1携带者的淋巴细胞裂解水平升高（24.5% vs. 16.4%），淋巴细胞异常（非典型、裂解和反应性淋巴细胞合并，45.7% vs. 35.4%）， γ -谷氨酰转移酶水平升高（21.2 vs. 19.6 IU/L），嗜酸性粒细胞计数降低（2.6% vs. 3.1%）。在携带者中，HTLV-1抗体滴度（n = 482）与平均红细胞体积呈负相关（r = -0.10），与总蛋白（r = 0.16）、磷（r = 0.12）、乳酸脱氢酶（r = 0.24）水平呈正相关。htlv -1原病毒载量（n = 326）在淋巴细胞分裂和任何淋巴细胞异常的携带者中较高。原病毒载量与血红蛋白（r = -0.11）、平均红细胞体积（r = -0.15）、中性粒细胞（r = -0.12）、嗜酸性粒细胞（r = -0.19）水平呈负相关，与乳酸脱氢酶水平呈正相关（r = 0.12）。男性受试者的原病毒载量明显高于女性受试者。288名参与者中有35人（12.1%）检测到粪球菌抗体，但与HTLV-1状态、抗体滴度或原病毒载量无关。HTLV-1感染的标志物（感染状态、抗体滴度和原病毒载量）与血液学和生化改变有关，如淋巴细胞异常、贫血、嗜酸性粒细胞减少和乳酸脱氢酶水平升高。
Objective. We investigated changes in hematologic and biochemical parameters associated with human T lymphotropic virus type 1 (HTLV-1) infection, antibody titer, and provirus load. Additionally, on a subset of participants, we assessed the epidemiologic relationship of HTLV-1 with Strongyloides stercoralis.Methods. Among volunteer blood donors in Jamaica, HTLV-1 carriers (n = 482) were frequency matched with HTLV-1 negative subjects (n = 355) by age (+/-5 years), sex, and date of blood donation (+/-3 months). HTLV-1 antibody titer, provirus load, S. stercoralis IgG antibodies, complete blood cell count, blood chemistry, and urinalysis parameters were measured.Results. HTLV-1 carriers, compared with HTLV-1-negative individuals, had elevated levels of cleaved lymphocytes (24.5% vs. 16.4%), any lymphocyte abnormalities (atypical, cleaved, and reactive lymphocytes combined, 45.7% vs. 35.4%), and gamma-glutamyl transferase levels (21.2 vs. 19.6 IU/L), as well as lower eosinophil count (2.6% vs. 3.1%). Among carriers, HTLV-1 antibody titer (n = 482) was inversely correlated with mean corpuscular volume (r = -0.10) and positively correlated with levels of total protein (r = 0.16), phosphorus (r = 0.12), and lactate dehydrogenase (r = 0.24). HTLV-1-provirus load (n = 326) was higher among carriers with cleaved lymphocytes and any lymphocyte abnormalities. Provirus load was inversely correlated with hemoglobin (r = -0.11), mean corpuscular volume (r = -0.15), neutrophil (r = -0.12), and eosinophil (r = -0.19) levels and was positively correlated with lactate dehydrogenase levels (r = 0.12). Provirus load was significantly higher among male than female subjects. S. stercoralis antibodies were detected in 35 (12.1%) of 288 participants but were not associated with HTLV-1 status, antibody titer, or provirus load.Conclusions. Markers of HTLV-1 infection (infection status, antibody titer, and provirus load) are associated with hematologic and biochemical alterations, such as lymphocyte abnormalities, anemia, decreased eosinophils, and elevated lactate dehydrogenase levels.