INHIBITION OF ANTRAL AND PYLORIC ELECTRICAL-ACTIVITY BY VAGAL AFFERENT STIMULATION IN THE RABBIT
INHIBITION OF ANTRAL AND PYLORIC ELECTRICAL-ACTIVITY BY VAGAL AFFERENT STIMULATION IN THE RABBIT
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DOI：
10.1016/0165-1838(87)90140-8
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发表时间：
1987-04-01
期刊：
影响因子：
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通讯作者：
ROUSSEAU, JP
中科院分区：
文献类型：
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作者：
DELOOF, S;BENNIS, M;ROUSSEAU, JP
刺激颈迷走神经传入纤维对豚鼠肌电活动的影响在清醒的和去皮质的，curarized兔胃窦和幽门的研究。在后一组中，以10-15 Hz（0.3-0.4 mA; 5-7 ms持续时间）刺激抑制胃窦和幽门e.m.g.。在21只家兔中，在另外两只家兔中引起兴奋性反应，但在其余13只家兔中没有产生变化。抑制反应不受乙啶（1 mg/kg，i. v.）的影响，酚妥拉明（lmg/kg，i. v.）或普萘洛尔（0.1mg/kg，i. v.）切断对侧颈迷走神经和双侧内脏神经，摘除腹腔神经节和双侧肾上腺，仍能持续。只有颈1、颈2节段脊髓和对侧迷走神经联合切断才能消除这种效应。在清醒家兔中，2-5 Hz（0.4 mA; 0.5-1.0 ms持续时间）的迷走神经刺激持续抑制胃窦和幽门e.m.g.。在酚妥拉明、普萘洛尔和纳洛酮（0.25-1.00 mg/kg）存在下，以及在切断内脏神经和摘除腹腔神经节的肾上腺切除家兔中，这种抑制反应持续存在。然而，它被完全取消的横膈上方的部分迷走神经。结果表明：（1）迷走神经传入对胃电活动的抑制起重要作用;（2）胃肌电的抑制作用与腹迷走神经有关;是由非肾上腺素纤维介导的，其中一组从胸脊髓出来，通过星状神经节与胸迷走神经相连。
The effects of stimulation of cervical vagal afferents on the electromyographic activity (e.m.g.) of the gastric antrum and pylorus have been studied both in conscious and decorticate, curarized rabbits. In the latter group, stimulation at 10-15 Hz (0.3-0.4 mA; 5-7 ms duration) inhibited both the antral and pyloric e.m.g. in 21 rabbits, elicited an excitatory response in two more but produced no change in the remaining 13 animals. The inhibitory response was not affected by guanethidine (1 mg/kg, i.v.), phentolamine (1 mg/kg, i.v.) or propranolol (0.1 mg/kg, i.v.) and persisted in rabbits in which the contralateral cervical vagus and both splanchnic nerves had been cut, the coeliac ganglia and both adrenal glands had been extirpated. It was only abolished by combined section of the spinal cord at the level of C1, C2 and the contralateral vagus in the neck. In conscious rabbits, vagal stimulation at 2-5 Hz (0.4 mA; 0.5-1.0 ms duration) consistently inhibited antral and pyloric e.m.g. This inhibitory response persisted in the presence of phentolamine, propranolol and naloxone (0.25-1.00 mg/kg), and in adrenalectomized rabbits with cut splanchnic nerves and extirpated coeliac ganglia. However, it was completely abolished by section of both vagi above the diaphragm. It is concluded that (1) the vagal afferents responsible for the inhibition of the gastric e.m.g. are already included in the abdominal vagus nerves, (2) this inhibition of gastric e.m.g. is mediated by non-adrenertic fibers, one group of them emerging from the thoracic spinal cord to join the thoracic vagi via the stellate ganglia.