Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma.
Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma.
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发表时间：
2013-10
影响因子：
2
通讯作者：
A. Shiozaki;Shingo Nakashima;D. Ichikawa;H. Fujiwara;H. Konishi;S. Komatsu;T. Kubota;K. Okamoto;Daisuke Iitaka;Hiroki Shimizu;Yoshito Nako;K. Takemoto;M. Kishimoto;E. Otsuji
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文献类型：
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作者：
A. Shiozaki;Shingo Nakashima;D. Ichikawa;H. Fujiwara;H. Konishi;S. Komatsu;T. Kubota;K. Okamoto;Daisuke Iitaka;Hiroki Shimizu;Yoshito Nako;K. Takemoto;M. Kishimoto;E. Otsuji
背景虽然p21是调节细胞周期进程的重要组成部分，但其在食管鳞状细胞癌（ESCC）中的临床病理学意义尚未达成共识。在本研究中，我们研究了食管鳞癌中其预后意义以及与细胞周期蛋白-D1 (CCND1) 表达的相关性。材料和方法通过免疫组织化学法计算取自接受根治性食管切除术的 69 例 ESCC 患者原发肿瘤样本的 p21 标记指数 (LI)，并研究 p21 LI 与各种临床病理特征、预后和 CCND1 LI 之间的相关性。结果这些肿瘤的p21 LI范围为2.0%至57.0%（中位数=28.4%，平均值±SD=27.3%±13.0）。 p21 LI 与 CCND1 LI 呈正相关。当使用p21 LI截断值30%将患者分为两组时，p21 LI≥30%患者的5年生存率为80.0%，显着高于p21 LI<30%患者的5年生存率（55.5%）。此外，根据p21和CCND1表达将患者分为四组时，p21 LI <30%和CCND1 LI≥45%的患者5年生存率最低（44.4%）。多变量分析表明静脉侵犯、淋巴管侵犯和p21 LI是独立的预后因素。结论 我们的结果表明，p21 LI 与 CCND1 LI 相关，在选择合适的截止值后，可以用作 ESCC 患者的独立预后因素。
BACKGROUND Although p21 is an important component that regulates cell-cycle progression, no consensus has been reached about its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance and correlation with cyclin-D1 (CCND1) expression in ESCC. MATERIALS AND METHODS The p21 labeling index (LI) was calculated by immunohistochemistry for 69 primary tumor samples obtained from patients with ESCC who had undergone curative esophagectomy, and correlations between p21 LI and various clinicopathological features, prognosis, and CCND1 LI were studied. RESULTS The p21 LI of these tumors ranged from 2.0% to 57.0% (median=28.4%, mean±SD=27.3% ± 13.0). p21 LI was positively correlated with CCND1 LI. When patients were divided into two groups using a p21 LI cut-off value of 30%, the 5-year survival rate of patients with p21 LI of ≥ 30% was 80.0%, which was significantly higher than that of patients with p21 LI of <30% (55.5%). Furthermore, when patients were divided into four groups according to p21 and CCND1 expression, the 5-year survival rate of patients with p21 LI of <30% and CCND1 LI of ≥ 45% was the lowest (44.4%). Multivariate analysis demonstrated that venous invasion, lymphatic invasion, and p21 LI were independent prognostic factors. CONCLUSION Our results indicate that p21 LI is correlated with CCND1 LI and can be used as an independent prognostic factor for patients with ESCC following selection of a suitable cut-off value.