DOES VITAMIN-A ACT ON PATTERN-FORMATION VIA THE EPIDERMIS OR THE MESODERM
DOES VITAMIN-A ACT ON PATTERN-FORMATION VIA THE EPIDERMIS OR THE MESODERM
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DOI：
10.1002/jez.1402300307
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
MADEN, M
中科院分区：
文献类型：
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作者：
MADEN, M
为了确定是否维生素A对图案形成的影响，在再生蝾螈[Ambystoma mexicanum]肢体是由于在芽基中胚层或表皮的变化，组织移植物之间交换正常和视黄酸处理的动物。结果是决定性的。处理的表皮和未处理的中胚层的组合导致正常的再生。经处理的中胚层和未经处理的表皮的组合产生再生体，其在proximodistal轴中连续复制，就像对照一样。维生素A显然作用于芽基的中胚层细胞，引起近中胚层的复制。
To determine whether the effect of vitamin A on pattern formation in the regenerating axolotl [Ambystoma mexicanum] limb was due to a change in the blastemal mesoderm or the epidermis, tissue grafts were exchanged between normal and retinoic acid-treated animals. The results were conclusive. The combination of treated epidermis and untreated mesoderm resulted in normal regenerates. The combination of treated mesoderm and untreated epidermis produced regenerates that were serially duplicated in the proximodistal axis just as the controls were. Vitamin A apparently acts on the mesodermal cells of the blastema in causing proximodistal duplications.