Prognostic and Clinicopathological Significance of ARID1A in Endometrium-Related Gynecological Cancers: A Meta-Analysis
Prognostic and Clinicopathological Significance of ARID1A in Endometrium-Related Gynecological Cancers: A Meta-Analysis
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ARID1A 在子宫内膜相关妇科癌症中的预后和临床病理学意义：荟萃分析。
DOI：
10.1002/jcb.26109
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发表时间：
2017-12-01
影响因子：
4
通讯作者：
Jia, Xuemei
中科院分区：
文献类型：
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作者：
Liu, Guangquan;Xu, Pengfei;Jia, Xuemei
肿瘤抑制基因AT Rich Interactive Domain 1A（ARID 1A）突变在多种肿瘤中均有报道，尤其是子宫内膜相关的妇科肿瘤，包括卵巢透明细胞癌、卵巢类上皮性癌和子宫类上皮性癌。然而，ARID 1A在子宫内膜相关妇科癌症中的预后价值仍然没有定论。因此，我们进行了这项荟萃分析，以评估ARID 1A在子宫内膜相关妇科癌症中的临床意义。通过系统检索Pubmed、科克伦图书馆和Web of Science中截至2016年9月的所有相关研究，纳入了11项研究，1,432例患者。提取所有研究特征和预后数据。使用固定效应或随机效应模型合并风险比（HR）和95%置信区间（CI）。我们的研究结果表明，ARID 1A阴性表达预测较短的无进展生存期（PFS，HR，1.84; 95%CI，1.32-2.57，P=0.000）的子宫内膜相关的妇科癌症患者，尤其是OCCC患者和日本患者。此外，在总体分析中发现朝向相同方向的边际趋势（OS，HR，1.34; 95%CI，0.93-1.93，P=0.112）。此外，ARID 1A阴性表达与子宫内膜相关妇科肿瘤的FIGO分期之间存在显著相关性，但与其他特征无关。J.细胞。118：4517-4525，2017. (c)2017 Wiley Periodicals，Inc.
The tumor suppressor gene, AT Rich Interactive Domain 1A (ARID1A) mutation has been reported in a variety of cancers, especially the endometrium-related gynecological cancers, including the ovarian clear cell carcinoma, ovarian endometrioid carcinoma, and uterine endometrioid carcinoma. However, the prognostic value of ARID1A in endometrium-related gynecological cancers is still inconclusive. Therefore, we performed this meta-analysis to evaluate the clinical significance of ARID1A in endometrium-related gynecological cancers. By systematically searching all the relevant studies from Pubmed, Cochrane Library, and Web of Science up to September 2016, 11 studies with 1,432 patients were included. All the study characteristics and the prognostic data were extracted. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using the fixed-effect or random-effect model. Our results indicated that negative ARID1A expression predicted shorter Progression free survival (PFS, HR, 1.84; 95%CI, 1.32-2.57, P=0.000) of patients with endometrium related gynecological cancers, especially the patiently with OCCC and the patients in Japan. Besides, a marginal trend towards the same direction was found in the Overall analysis (OS, HR, 1.34; 95%CI, 0.93-1.93, P=0.112). Furthermore, the significant correlation was achieved between the negative ARID1A expression and the FIGO stage of endometrium-related gynecological cancers, but not the other characteristics. J. Cell. Biochem. 118: 4517-4525, 2017. (c) 2017 Wiley Periodicals, Inc.