Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans
Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans
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DOI：
10.1016/s8756-3282(97)00052-5
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发表时间：
1997-06-01
期刊：
影响因子：
4.1
通讯作者：
Alexandre, C
中科院分区：
文献类型：
--
作者：
Collet, P;Uebelhart, D;Alexandre, C
分析了在俄罗斯和平号空间站分别呆了1个月和6个月的两名宇航员的骨矿物质密度和探索骨细胞活性的生化参数。在飞行前、飞行后和恢复期后进行了测量。在第一个月结束时，外周QCT测量表明胫骨远端干骺端的骨小梁质量略有下降，然而，在6个月的太空飞行后，在胫骨中观察到更明显的骨小梁和皮质骨损失，并且在骨小梁室中6个月恢复后仍然显著，而在皮质包膜中不再观察到减少。在任何时间都没有观察到桡骨远端的任何室的变化，跟骨的超声BUA在第一个月时大大降低，超声SOS没有检测到变化，反映骨形成活性的参数在两次任务后似乎都受到抑制，相反，除了吡啶啉增加的趋势外，没有观察到吸收参数的显著变化。总之，在航天飞行引起的骨丢失方面，下承重骨似乎比上承重骨更敏感，这可能解释了没有显著的全身生化数据变化。本研究进一步表明，着陆后6个月胫骨骨小梁室的恢复在6个月的使命后没有完成。(C)Elsevier Science Inc.出版。
The bone mineral density and the biochemical parameters exploring bone cell activities were analyzed in two cosmonauts who spent 1 and 6 months, respectively, in the Russian MIR station, Measurements were performed before the flight, after the flight, and after a recovery period, At the end of the first month, peripheral QCT measurements indicated a slight decrease of trabecular bone mass in the distal tibial metaphysis, However, after 6 months of spaceflight, a more marked loss of trabecular and cortical bones was observed in the tibia, and was still significant after 6 month recovery in the trabecular compartment, whereas a decrease was no longer observed in the cortical envelope, No change was observed in either compartment of the distal radius at any time, Ultrasound BUA of the calcaneus was greatly reduced by the first month, followed by a more dramatic decrease after month 6, Ultrasound SOS detected no change, Parameters reflecting bone formation activity appeared to be depressed after both missions, In contrast, no dramatic change in resorption parameters was observed, except for a trend toward an increase in pyridinoline. In conclusion, the lower weight-bearing bones appeared more sensitive than the upper ones in terms of spaceflight-induced bone loss, This probably explained the absence of marked systemic biochemical data changes, This study further suggests that recovery in the tibial trabecular compartment 6 months after landing was not completed after a 6 month mission. (C) 1997 by Elsevier Science Inc.