Interrogating the relationship between naïve and immune antiviral T cell repertoires.
Interrogating the relationship between naïve and immune antiviral T cell repertoires.
复制标题
DOI：
10.1016/j.coviro.2013.06.011
复制
发表时间：
2013-08
影响因子：
5.9
通讯作者：
Thomas, Paul G.
中科院分区：
文献类型：
--
作者：
La Gruta, Nicole L.;Thomas, Paul G.
Understanding how naïve virus-specific CD8+ T cells influence the type of immune response generated after virus infection is critical for the development of enhanced therapeutic and vaccination strategies to exploit CD8+ T cell-mediated immunity. Recent technological advances in T cell isolation and T receptor sequencing have allowed for greater understanding of the basic structure of immune T cell repertoires, the diversity of responses within and between individuals, and changes in repertoires over time and in response to infection conditions. In this review, we discuss the current understanding of how T cell repertoires contribute to potent antiviral responses. Additionally we compare the state of the art in receptor sequencing, highlighting the advantages and disadvantages of the three most common approaches: next-generation sequencing, template-switch anchored RT-PCR, and multiplex single cell PCR. Finally, we describe how TCR sequencing has delineated the relationship between naïve and immune T cell repertoires.
登录
查看更多内容
影响因子：
4.4
作者：
Gillespie, Geraldine M. A.;Stewart-Jones, Guillaume;Rowland-Jones, Sarah L.
通讯作者：
Rowland-Jones, Sarah L.
影响因子：
4.4
作者：
Charini, WA;Kuroda, MJ;Letvin, NL
通讯作者：
Letvin, NL
影响因子：
3.7
作者：
Sun X;Saito M;Sato Y;Chikata T;Naruto T;Ozawa T;Kobayashi E;Kishi H;Muraguchi A;Takiguchi M
通讯作者：
Takiguchi M
影响因子：
32.4
作者：
Moon, James J.;Chu, H. Hamlet;Jenkins, Marc K.
通讯作者：
Jenkins, Marc K.
DOI：
10.4049/jimmunol.1102661
发表时间：
2012-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jenkins MK;Moon JJ
通讯作者：
Moon JJ