The influence of age on bone mineral regulating hormones.
The influence of age on bone mineral regulating hormones.
复制标题
年龄对骨矿物质调节激素的影响。
DOI：
10.1016/8756-3282(86)90001-3
复制
发表时间：
1986
期刊：
影响因子：
4.1
通讯作者：
JohnstonJr,CC
中科院分区：
文献类型：
--
作者：
Epstein,S;Bryce,G;Hinman,JW;Miller,ON;Riggs,BL;Hui,SL;JohnstonJr,CC
本研究的目的是确定年龄对正常健康男性和女性血液中1，25-二羟维生素D（1，25（OH）2D）和免疫反应性甲状旁腺激素（iPTH）水平的影响。共855名正常受试者（361名男性和494名女性）进行了研究。结果表明，对于健康男性，1，25（OH）2D的血液浓度基本上保持不变，随着年龄的增长，直到65岁，然后浓度显着下降。对于健康女性，1，25（OH）2D增加到65岁，然后以显着的速度下降。男性血清iPTH随年龄增长而增加，但65岁后增加速度更快。在女性中，iPTH浓度的显著增加直到65岁以后才发生。男性和女性的血清肌酐均随年龄增长而增加。
The objective of this study was to determine the effect of age on the blood levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) and immunoreactive parathyroid hormone (iPTH) in normal, healthy males and females. A total of 855 normal subjects (361 males and 494 females) were studied. The results show that for healthy males, blood concentrations of 1,25(OH)2D remained essentially constant with increasing age up to age 65, and then the concentrations decreased significantly. For healthy females, 1,25(OH)2D increased up to age 65, and then decreased at a significant rate. Serum iPTH in males increased with advancing age, but the rate of increase was greater after age 65. In females a significant increase in iPTH concentrations did not occur until after age 65. Serum creatinine increased in both males and females with advancing age.