Partners for adenosine A1 receptors
Partners for adenosine A1 receptors
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DOI：
10.1385/jmn:26:2-3:221
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发表时间：
2005-01-01
影响因子：
3.1
通讯作者：
Lluis, C
中科院分区：
文献类型：
--
作者：
Franco, R;Ciruela, F;Lluis, C
G蛋白偶联受体(GPCRs)是多种神经系统疾病的治疗靶点。本文以腺苷A(2)受体(A(1)Rs)作为GPCRs的研究范式，重点阐述了从单体到异构体的蛋白质相互作用如何有助于激素/神经递质/神经调节剂的调节。A(1)Rs与其他膜受体、酶、适配器和支架蛋白的相互作用与受体的运输、内化和脱敏有关，A(1)Rs在通过不同的细胞内途径驱动信号传递方面起着极其重要的作用。甚至有可能将GPCR异构体与离子通道受体连接在一个受体镶嵌中，这可能具有特殊的整合价值，并可能构成学习和记忆的分子基础。
G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological diseases. Using adenosine A(2) receptors (A(1)Rs) as paradigm of GPCRs, this review focuses on how protein-protein interactions from monomers to heteromers, can contribute to hormone/neurotransmitter/neuromodulator regulation. The interaction of A(1)Rs with other membrane receptors, enzymes, and adaptor and scaffolding proteins is relevant for receptor traffic, internalization, and desensitization, and A(1)Rs are extremely important in driving signaling through different intracellular pathways. There is even the possibility of linking together GPCR heteromeric complexes with ion channel receptors in a receptor mosaic that might have special integrative value and might constitute the molecular basis for learning and memory.