Multipathogen infections in hospitalized children with acute respiratory infections.
Multipathogen infections in hospitalized children with acute respiratory infections.
复制标题
急性呼吸道感染住院儿童的多病原体感染
DOI：
10.1186/1743-422x-6-155
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发表时间：
2009-09-29
期刊：
影响因子：
4.8
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Peng D;Zhao D;Liu J;Wang X;Yang K;Xicheng H;Li Y;Wang F
目的探讨急性呼吸道感染（阿尔蒂）住院患儿多病原体感染的流行病学、临床特点及相互关系。对因阿尔蒂入院的儿童进行了一项前瞻性研究。通过间接免疫荧光法分析外周血样本，以检测呼吸道病原体，包括呼吸道合胞病毒、腺病毒、A型和B型流感病毒（Flu）、1型、2型和3型副流感病毒（PIV）、肺炎衣原体和肺炎支原体。每一个孩子的病史taked.ResultsRespiratory代理人检测到164（51.9%）的316名儿童与阿尔蒂。50名（15.8%）儿童被确定为单一药物，114名（36.1%）儿童被确定为多种药物。甲型流感病毒是最常检出的病原体，其次是乙型流感病毒B。合并感染主要发生在8月份，在3至6岁的儿童中更常见。甲型流感病毒，流感B，PIV 1的比例显着较高的样本中检测到两个或两个以上的病原体，每个样品比在样品中与一个单一的病原体。ConclusionOur研究表明，有一个高发生率的多病原体感染的儿童承认与阿尔蒂和合并感染与某些病原体。
BackgroundTo explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in hospitalized children with acute respiratory tract infection (ARTI). A prospective study of children admitted with ARTI was conducted. Peripheral blood samples were analyzed by indirect immunofluorescence to detect respiratory agents including respiratory syncytial virus; adenovirus; influenza virus (Flu) types A and B; parainfluenza virus (PIV) types 1, 2, and 3; chlamydia pneumonia; and mycoplasma pneumonia. A medical history of each child was taken.ResultsRespiratory agents were detected in 164 (51.9%) of 316 children with ARTI. A single agent was identified in 50 (15.8%) children, and multiple agents in 114 (36.1%). Flu A was the most frequently detected agent, followed by Flu B. Coinfection occurred predominantly in August and was more frequent in children between 3 and 6 years of age. A significantly higher proportion of Flu A, Flu B, and PIV 1 was detected in samples with two or more pathogens per sample than in samples with a single pathogen.ConclusionOur study suggests that there is a high occurrence of multipathogen infections in children admitted with ARTI and that coinfection is associated with certain pathogens.