Predictors of hemoglobin A1c in a national sample of nondiabetic children - The Third National Health and Nutrition Examination Survey, 1988-1994
Predictors of hemoglobin A1c in a national sample of nondiabetic children - The Third National Health and Nutrition Examination Survey, 1988-1994
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DOI：
10.1093/aje/kwg023
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发表时间：
2003-04-01
影响因子：
5
通讯作者：
Lipton, RB
中科院分区：
文献类型：
--
作者：
Eldeirawi, K;Lipton, RB
血红蛋白A1 c（HbA 1c）与糖尿病和非糖尿病患者的葡萄糖代谢有关。分析与HbA 1c相关的因素可能有助于研究人员更好地识别患2型糖尿病可能性增加的儿童。在这项研究中，作者调查了1，700名墨西哥裔美国人、1，787名非洲裔美国人和1，441名非西班牙裔白色年轻人中HbA 1c百分比的预测因素，这些年轻人年龄在4-17.0岁之间，没有糖尿病，并在第三次全国健康和营养检查调查（1988-1994）中进行了检查。HbA 1c与年龄和体重指数呈正相关（分别为p=0.065和p=0.008），与社会经济状况指标贫困收入比呈负相关（p=0.008）。非裔美国人和墨西哥裔美国人的平均HbA 1c百分比高于非西班牙裔白人，数据控制了年龄，性别，体重指数，孕产妇体重指数和贫困收入比。虽然出现了一些不一致，但HbA 1c通常与年轻人2型糖尿病的其他已知危险因素相关。本报告提供了非糖尿病儿童中HbA 1c百分比的代表性数据。然而，还需要进一步调查。更好地了解HbA 1c的效用及其与青年2型糖尿病的关系。
Hemoglobin A1c (HbA1c) is related to glucose metabolism in diabetic and nondiabetic persons. Analysis of factors related to HbA1c may help researchers to better identify children with an increased likelihood of developing type 2 diabetes mellitus. In this study, the authors investigated predictors of HbA1c percentage among 1,700 Mexican-American, 1,787 African-American, and 1,441 non-Hispanic White young people aged 4-17.0 years who were free of diabetes and were examined in the Third National Health and Nutrition Examination Survey (1988-1994). HbA1c was positively related to age and body mass index (p=0.065 and p=0.008, respectively) and negatively related to an indicator of socioeconomic status, the poverty income ratio (p=0.008). African Americans and Mexican Americans had higher mean HbA1c percentages than non-Hispanic Whites after data were controlled for age, sex, body mass index, maternal body mass index, and poverty income ratio. While some inconsistencies emerged, HbA1c Was generally associated with other known risk factors for type 2 diabetes in young people. This report provides representative data on HbA1c percentage among nondiabetic children. However, further investigation will be needed. to better understand the utility of HbA1c and its relation to type 2 diabetes in youth.