Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
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DOI：
10.3389/fimmu.2018.01451
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发表时间：
2018
影响因子：
7.3
通讯作者：
Tomlinson MG
中科院分区：
文献类型：
--
作者：
Matthews AL;Koo CZ;Szyroka J;Harrison N;Kanhere A;Tomlinson MG
去整合素和金属蛋白酶10(ADAM10)是一种普遍存在的跨膜蛋白，其功能是作为分子剪刀将细胞外区域从其跨膜靶蛋白中分离出来。ADAM10是决定细胞命运的Notch蛋白的配体依赖的激活剂。事实上，在小鼠中，ADAM10的条件性基因敲除表明B细胞、T细胞和髓系细胞的发育和/或功能受损。ADAM10能裂解许多其他白细胞表达的底物。在B细胞上，低亲和力的IgE受体CD23的ADAM10裂解促进过敏和哮喘，ICOS配体的裂解削弱抗体反应，BAFF-APRIL受体跨膜激活剂和CAML相互作用因子以及BAFF受体的裂解降低B细胞的存活率。在小胶质细胞上，髓系细胞2上表达的清道夫受体触发受体的一种罕见变体的ADAM10裂解增加可能增加阿尔茨海默病的易感性。我们和其他人最近发现ADAM10与六种不同的调节性Tspanin膜蛋白之一相互作用，我们称之为TspanC8亚组，包括Tspan5、Tspan10、Tspan14、Tspan15、Tspan17和Tspan33。TspanC8是ADAM10离开内质网所必需的，越来越多的证据表明，它们决定了ADAM10的亚细胞定位和底物特异性。因此，我们认为ADAM10不应该被视为单一的剪刀，而是六种不同的剪刀，具有不同的底物特异性，这取决于相关的TspanC8。在这篇综述中，我们整理了最近的转录数据，介绍了白细胞的TspanC8剪刀，并讨论了六个TspanC8/ADAM10剪刀在白细胞发育和功能中的潜在作用。
A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane protein that functions as a “molecular scissor” to cleave the extracellular regions from its transmembrane target proteins. ADAM10 is well characterized as the ligand-dependent activator of Notch proteins, which control cell fate decisions. Indeed, conditional knockouts of ADAM10 in mice reveal impaired B-, T-, and myeloid cell development and/or function. ADAM10 cleaves many other leukocyte-expressed substrates. On B-cells, ADAM10 cleavage of the low-affinity IgE receptor CD23 promotes allergy and asthma, cleavage of ICOS ligand impairs antibody responses, and cleavage of the BAFF–APRIL receptor transmembrane activator and CAML interactor, and BAFF receptor, reduce B-cell survival. On microglia, increased ADAM10 cleavage of a rare variant of the scavenger receptor triggering receptor expressed on myeloid cells 2 may increase susceptibility to Alzheimer’s disease. We and others recently showed that ADAM10 interacts with one of six different regulatory tetraspanin membrane proteins, which we termed the TspanC8 subgroup, comprising Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33. The TspanC8s are required for ADAM10 exit from the endoplasmic reticulum, and emerging evidence suggests that they dictate ADAM10 subcellular localization and substrate specificity. Therefore, we propose that ADAM10 should not be regarded as a single scissor, but as six different scissors with distinct substrate specificities, depending on the associated TspanC8. In this review, we collate recent transcriptomic data to present the TspanC8 repertoires of leukocytes, and we discuss the potential role of the six TspanC8/ADAM10 scissors in leukocyte development and function.
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DOI：
10.1084/jem.20091990
发表时间：
2010-03-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gibb DR;El Shikh M;Kang DJ;Rowe WJ;El Sayed R;Cichy J;Yagita H;Tew JG;Dempsey PJ;Crawford HC;Conrad DH
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Conrad DH
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DOI：
10.1007/s00018-015-2111-z
发表时间：
2016-05
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
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作者：
Jouannet S;Saint-Pol J;Fernandez L;Nguyen V;Charrin S;Boucheix C;Brou C;Milhiet PE;Rubinstein E
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Rubinstein E
影响因子：
4.8
作者：
Lemieux, George A.;Blumenkron, Fernando;Werb, Zena
通讯作者：
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DOI：
10.4049/jimmunol.1302042
发表时间：
2013-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Folgosa L;Zellner HB;El Shikh ME;Conrad DH
通讯作者：
Conrad DH
DOI：
10.1073/pnas.0500918102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Maretzky, T;Reiss, K;Saftig, P
通讯作者：
Saftig, P