Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.
Crawling and turning in a minimal reaction-diffusion cell motility model: Coupling cell shape and biochemistry.
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DOI：
10.1103/physreve.95.012401
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Rappel WJ
中科院分区：
文献类型：
--
作者：
Camley BA;Zhao Y;Li B;Levine H;Rappel WJ
我们研究了一个爬行的真核细胞的最小模型，该模型具有由描述Rho GTP酶动力学的反应扩散机制控制的化学极性。细胞的大小、形状和速度是由控制肌动蛋白聚合位置的化学极性和细胞的物理性质(包括其膜张力)共同决定的。在我们的模型中，我们发现了两种高度持久的轨迹，一种是细胞以直线爬行，另一种是转弯轨迹，细胞从直线爬行过渡到圆形爬行。我们讨论了这种转折不稳定性的控制变量，并认为转折是由反应扩散机制和电池形状之间的耦合引起的。这强调了细胞力学和生物化学之间的简单联系可以产生的令人惊讶的特征。我们的结果表明，类似的不稳定性可能存在于对细胞极性的广泛的生化描述中。
We study a minimal model of a crawling eukaryotic cell with a chemical polarity controlled by a reaction-diffusion mechanism describing Rho GTPase dynamics. The size, shape, and speed of the cell emerge from the combination of the chemical polarity, which controls the locations where actin polymerization occurs, and the physical properties of the cell, including its membrane tension. We find in our model both highly persistent trajectories, in which the cell crawls in a straight line, and turning trajectories, where the cell transitions from crawling in a line to crawling in a circle. We discuss the controlling variables for this turning instability and argue that turning arises from a coupling between the reaction-diffusion mechanism and the shape of the cell. This emphasizes the surprising features that can arise from simple links between cell mechanics and biochemistry. Our results suggest that similar instabilities may be present in a broad class of biochemical descriptions of cell polarity.