Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol: the NHLBI Family Heart Study.
Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol: the NHLBI Family Heart Study.
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生活方式习惯的相似性对高密度脂蛋白和低密度脂蛋白胆固醇家族聚集的影响：NHLBI 家庭心脏研究。
DOI：
10.1093/oxfordjournals.aje.a010099
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发表时间：
1999
影响因子：
5
通讯作者：
Province,MA
中科院分区：
文献类型：
--
作者：
Ellison,RC;Myers,RH;Zhang,Y;Djoussé,L;Knox,S;Williams,RR;Province,MA
一般认为，脂质的家族聚集与遗传和共同的环境因素有关。为了确定生活习惯的家族相似性在多大程度上解释了高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇的家族聚集性，作者分析了1994-1996年国家心肺血液研究所家庭心脏研究中2,284名美国成年参与者的数据。对于男性和女性，HDL胆固醇分别与饮酒（r= 0.27，p < 0.001;r= 0.21，p < 0.001）、运动（r= 0.06，p = 0.05;r= 0.10，p = 0.002）和吸烟（r=-0.09，p = 0.005;r=-0.13，p = 0.001）相关。高密度脂蛋白胆固醇有很强的家族聚集性（父母-子女，r= 0.32;同胞-同胞，r= 0.29），但不到10%是由生活习惯解释的。对于低密度脂蛋白胆固醇，男性中总脂肪（r= 0.06，p = 0.07）和水果/蔬菜（r=-0.09，p = 0.005）的摄入量以及女性中吸烟（r= 0.10，p = 0.002）的摄入量之间存在弱相关性。LDL胆固醇在家庭成员之间有很强的相关性（父母-子女，r= 0.24;兄弟姐妹-兄弟姐妹，r= 0.31），但基本上没有这种聚集与研究的生活方式因素有关。这项研究表明，生活方式因素对高密度脂蛋白和低密度脂蛋白胆固醇的家族聚集性几乎没有影响。美国流行病学杂志1999;150：910-18。
It is generally assumed that familial aggregation of lipids relates to both genetic and shared environmental factors. To determine the degree to which familial similarities in lifestyle habits explain familial aggregation of high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, the authors analyzed 1994–1996 data from 2,284 US adult participants in the National Heart, Lung, and Blood Institute Family Heart Study. For men and women, respectively, HDL cholesterol correlated with alcohol consumption (r= 0.27,p< 0.001;r= 0.21,p< 0.001), exercise (r= 0.06,p= 0.05;r= 0.10,p= 0.002), and smoking (r= −0.09,p= 0.005;r= −0.13,p< 0.001). There was strong familial aggregation of HDL cholesterol (parent-child,r= 0.32; sibling-sibling,r= 0.29), but less than 10% was explained by lifestyle habits. For LDL cholesterol, weak correlations were found for intake of total fat (r= 0.06,p= 0.07) and fruits/vegetables (r= −0.09,p= 0.005) among men and for smoking (r= 0.10,p= 0.002) among women. LDL cholesterol correlated strongly among family members (parent-child,r= 0.24; sibling-sibling,r= 0.31), but essentially none of this aggregation related to the lifestyle factors studied. This study suggests that lifestyle factors have little effect on the familial aggregation of HDL and LDL cholesterol.Am J Epidemiol1999;150:910-18.