Gray and white matter imbalance - Typical structural abnormality underlying classic autism?
Gray and white matter imbalance - Typical structural abnormality underlying classic autism?
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DOI：
10.1016/j.braindev.2007.11.006
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发表时间：
2008-06-01
影响因子：
1.7
通讯作者：
Steiner, Carlos E.
中科院分区：
文献类型：
--
作者：
Bonilha, Leonardo;Cendes, Fernando;Steiner, Carlos E.
最近的证据支持自闭症患者皮质活动增加和大脑连通性受损，但这些异常的结构相关性尚未确定。我们对自闭症患者的脑MRI进行了基于体素的形态计量分析，这些患者是从103名普适性发育障碍患者中挑选出来的。12例男性患者的平均年龄为12.4+/-4岁，与16名匹配的对照组进行比较。自闭症患者额叶内侧和背外侧、颞叶内侧和内侧、顶叶、小脑和屏状回灰质增加。额叶、顶叶、颞叶和枕叶白质减少。皮质扩大和白质减少的组合可能是典型自闭症一些症状的结构基础。(C)2007 Elsevier B.V.保留所有权利。
Recent evidence supports increased cortical activity and impaired brain connectivity in autism, but the structural correlates of these abnormalities are not yet defined. We performed a voxel based morphometry analysis of brain MRI from patients with autism selected from a group of 103 subjects with pervasive developmental disorders. Twelve male patients with mean age of 12.4 +/- 4 years were compared with 16 matched controls. Patients with autism exhibited increase in gray matter in medial and dorsolateral frontal areas, in the lateral and medial parts of the temporal lobes, in the parietal lobes, cerebellum and claustrum. Patients also showed decrease in frontal, parietal, temporal and occipital white matter. The combination of enlarged cortex and reduced white matter is possibly the structural basis of some symptoms of classic autism. (C) 2007 Elsevier B.V. All rights reserved.