Two or more significant life-events in 6-months are associated with lower rates of HIV treatment and virologic suppression among youth with HIV in Uganda and Kenya.
Two or more significant life-events in 6-months are associated with lower rates of HIV treatment and virologic suppression among youth with HIV in Uganda and Kenya.
复制标题
乌干达和肯尼亚艾滋病毒感染青年中，六个月内发生的两次或两次以上重大生活事件与艾滋病毒治疗和病毒学抑制率较低有关。
DOI：
10.1080/09540121.2022.2052260
复制
发表时间：
2023
期刊：
影响因子：
1.7
通讯作者：
Ruel,TheodoreD
中科院分区：
文献类型：
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作者：
Mwangwa,Florence;Charlebois,EdwinD;Ayieko,James;Olio,Winter;Black,Douglas;Peng,James;Kwarisiima,Dalsone;Kabami,Jane;Balzer,LauraB;Petersen,MayaL;Kapogiannis,Bill;Kamya,MosesR;Havlir,DianeV;Ruel,TheodoreD
撒哈拉以南非洲的艾滋病毒感染者的艾滋病毒护理结果很差。我们确定了肯尼亚和乌干达农村地区15-24岁的艾滋病毒感染者最近发生的重大生活事件与艾滋病毒抗逆转录病毒治疗（ART）启动和艾滋病毒抑制的关系。这是一项对995名参加青年研究的青年的横断面分析。在基线上，提供者评估了最近（6个月内）的生活事件，定义为学校/就业，居住，伙伴关系，疾病，监禁状况，家庭冲突或死亡，出生/怀孕，自我报告的饮酒，为人父母和艾滋病毒状况披露的变化。我们检查了事件的频率及其与ART状态和HIV病毒抑制（<400拷贝/ul）的相关性。近期发生的重大生活事件占57.7%。有>2个重大生活事件（aOR = 0.61，95%CI：0.45-0.85）和饮酒（aOR = 0.61，95%CI：0.43-0.87）与HIV病毒抑制的几率较低相关，而向伴侣（aOR = 2.39，95%CI：1.6-3.5）或家人（aOR = 1.86，95%CI：1.3-2.7）披露HIV状态（aOR = 1.8，95%CI：1.2-2.5）和单身（aOR = 1.6，95%CI：1.3-2.1）的几率较高。这表明，两个或两个以上的最近的生活事件和饮酒是关键的障碍，以抗逆转录病毒疗法的启动和实现病毒抑制青年艾滋病毒感染者在农村东非。ClinicalTrials.gov
Youth living with HIV in sub-Saharan Africa have poor HIV care outcomes. We determined the association of recent significant life-events with HIV antiretroviral treatment (ART) initiation and HIV viral suppression in youth aged 15–24 years living with HIV in rural Kenya and Uganda. This was a cross-sectional analysis of 995 youth enrolled in the SEARCH Youth study. At baseline, providers assessed recent (within 6 months) life-events, defined as changes in schooling/employment, residence, partnerships, sickness, incarceration status, family strife or death, and birth/pregnancy, self-reported alcohol use, being a parent, and HIV-status disclosure. We examined the frequencies of events and their association with ART status and HIV viral suppression (<400 copies/ul). Recent significant life-events were prevalent (57.7%). Having>2 significant life-events (aOR = 0.61, 95% CI:0.45-0.85) and consuming alcohol (aOR = 0.61, 95% CI:0.43-0.87) were associated with a lower odds of HIV viral suppression, while disclosure of HIV-status to partner (aOR = 2.39, 95% CI:1.6-3.5) or to family (aOR = 1.86, 95% CI:1.3-2.7), being a parent (aOR = 1.8, 95% CI:1.2-2.5), and being single (aOR = 1.6, 95% CI:1.3-2.1) had a higher odds. This suggest that two or more recent life-events and alcohol use are key barriers to ART initiation and achievement of viral suppression among youth living with HIV in rural East Africa.Trial registration:ClinicalTrials.gov identifier: NCT03848728..