Surveillance of respiratory viral infections among pediatric outpatients in northern Taiwan
Surveillance of respiratory viral infections among pediatric outpatients in northern Taiwan
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DOI：
10.1016/j.jcv.2003.08.014
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发表时间：
2004-05-01
影响因子：
8.8
通讯作者：
Tsao, KC
中科院分区：
文献类型：
--
作者：
Lin, TY;Huang, YC;Tsao, KC
背景：病毒是儿童上呼吸道感染的常见原因。像台湾一样，有几个病毒学监测系统的儿童呼吸道病毒感染在developing countries.Materials and Methods：在1995年8月和1997年7月，6-10咽拭子标本，每周从儿科门诊急性，发热性上呼吸道感染（URTI）。样本由长庚儿童医院的两位儿科医生随机抽取，送去进行病毒分离鉴定。共收集910份标本，365份标本（40%）至少对I型病毒呈阳性，包括81份肠道病毒、73份腺病毒、58份B型流感病毒、54份A型流感病毒、48份巨细胞病毒（CMV）、单纯疱疹病毒1型（HSV-1）25株，副流感病毒7株，呼吸道合胞病毒（RSV）3株，混合病毒16株。在整个研究期间鉴别出腺病毒和肠道病毒。腺病毒感染没有季节性变化，而肠道病毒感染在5月至7月以及9月至11月达到高峰。甲型和B型流感病毒分别在两个时期被发现，总之，几乎全年都可以检测到流感病毒。发现鉴定的病毒类型与患者平均年龄之间存在关联（ANOVA检验P值= 0.0001）。感染流感病毒的患者的平均年龄，无论是A或13，是显着高于感染腺病毒，HSV-1，CMV和肠道病毒的患者。结论：这项研究的结果表明，腺病毒和肠道病毒是两个最常见的病毒分离出的儿科门诊急性，发热性URTI，并可以确定在台湾北方全年。流感病毒也可以在全年和流行期间发现，5岁以上的儿童急性发热性URTI很可能是流感病例。(C)2003 Elsevier B. V.保留所有权利。
Background: Viruses are a frequent cause of upper respiratory tract infections in children. Like Taiwan, there were few virological surveillance systems for respiratory viral infections among children in developing countries.Materials and methods: During August 1995 and July 1997, 6-10 throat swab specimens per week were taken from pediatric outpatients with acute, febrile upper respiratory tract infections (URTI). The specimens were randomly obtained by two pediatricians at Chang Gung Children's Hospital and sent for virus isolation and identification.Results: A total of 910 specimens were collected and 365 specimens (40%) were positive for at least I virus and included 81 enterovirus, 73 adenovirus, 58 influenza B virus, 54 influenza A virus, 48 cytomegalovirus (CMV), 25 herpes simplex virus-1 (HSV-1), 7 parainfluenza virus, 3 respiratory syncytial virus (RSV) and 16 mixed viruses. Adenovirus and enterovirus were identified throughout the study period. No seasonal variation was noted for adenovirus while enterovirus peaked between May and July and also during September and November. Influenza viruses, both A and B, were identified during two periods, respectively and altogether, influenza viruses could be detected almost throughout the year. An association between the virus type identified and the mean age of patients was found (P-value = 0.0001 by ANOVA test). The mean age of patients infected with influenza viruses, either A or 13, was significantly higher than those of patients infected with adenovirus, HSV-1, CMV and enterovirus.Conclusion: The results of this study demonstrate that adenovirus and enterovirus are the two most common viruses isolated from pediatric outpatients with acute, febrile URTIs and can be identified throughout the year in northern Taiwan. Influenza viruses also can be identified throughout the year and during the epidemic, a child older than 5 years of age with acute febrile URTI is likely to be a case of influenza. (C) 2003 Elsevier B.V. All rights reserved.