α2-Adrenoreceptor agonist, dexmedetomidine, alters acute gene expression after global ischemia in gerbils
α2-Adrenoreceptor agonist, dexmedetomidine, alters acute gene expression after global ischemia in gerbils
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α2-肾上腺素受体激动剂右美托咪定改变沙鼠全身缺血后的急性基因表达
DOI：
10.1016/s0304-3940(97)00585-5
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发表时间：
1997
影响因子：
2.5
通讯作者：
J. Koistinaho
中科院分区：
文献类型：
--
作者：
M. Wittner;J. Sivenius;J. Koistinaho
应用定量原位杂交技术研究了选择性α2肾上腺素受体激动剂和神经保护剂右美托咪定对全脑缺血模型中即刻早期基因和热休克蛋白hsp 70表达的影响。在先前显示具有神经保护作用的剂量下，右美托咪啶抑制缺血后沙鼠海马中c-fos和hsp 70 mRNA的表达，不影响jun-B mRNA，并增强NGFI-A mRNA的诱导。c-fos和hsp 70的基因表达减少，检测到在CA 1锥体细胞，这是容易缺血变性，而增加的NGFI-A的基因表达，测量从CA 3和齿状回，区域相对耐缺血。这些早期基因表达的改变可能反映了α2-肾上腺素受体激动剂介导神经保护作用的机制。
The effect of dexmedetomidine, a selective α2-adrenoreceptor agonist and neuroprotective agent on the expression of immediate early genes and heat shock protein hsp70, was studied using quantitative in situ hybridization in a global ischemia model. At the dose previously shown to be neuroprotective dexmedetomidine inhibited the expression of c-fos and hsp70 mRNA, did not affect jun-B mRNA, and enhanced the induction of NGFI-A mRNA in the postischemic gerbil hippocampus. The reduced gene expression of c-fos and hsp70 was detected in the CA1 pyramidal cells which are prone to ischemic degeneration, whereas the increased gene expression of NGFI-A was measured from the CA3 and dentate gyrus, areas relatively resistant to ischemia. These alterations in early gene expression possibly reflect the mechanisms mediating the neuroprotective effects of α2-adrenoreceptor agonists.
影响因子：
8.8
作者：
MAIER, C;STEINBERG, GK;MAZE, M
通讯作者：
MAZE, M