Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
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暴露于野百合碱或脱氢逆松碱的大鼠组织中的肿瘤转化。
DOI：
10.1093/jnci/56.4.787
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
James R. Allen
中科院分区：
文献类型：
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作者：
Robert Shumaker;Kent Robertson;I. Hsu;James R. Allen
雄性SD大鼠每两周皮下注射一次吡咯里西丁生物碱野百合碱或其代谢物脱氢反式维甲酸1年。然后，这些动物又被观察了12个月，以诱导肿瘤的发生。在60只接受脱氢逆转录病毒治疗的大鼠中，39只在注射部位发生横纹肌肉瘤，其中5只肿瘤转移。在60只野百合碱处理的大鼠中，记录到31个广泛分布的不同细胞类型的肿瘤。组织反应不同的原因是代谢物去氢反式维甲素是一种最接近的致癌物质，而野百合碱必须首先被代谢，才能实现其致癌潜力。
Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. In the 60 monocrotaline-treated rats, 31 widely dispersed tumors of various cell types were recorded. The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinogen, whereas monocrotaline must first be metabolized before its carcinogenic potential is realized.