Tumor growth, weight loss and cytokines in SCID mice
Tumor growth, weight loss and cytokines in SCID mice
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DOI：
10.1016/s0304-3835(96)04519-3
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发表时间：
1997-01-01
期刊：
影响因子：
9.7
通讯作者：
Albertini, MR
中科院分区：
文献类型：
--
作者：
Murray, S;Schell, K;Albertini, MR
已经提出免疫调节细胞因子在癌症恶病质的发生和发展中起作用，尽管支持该理论的证据仍然不确定。在本研究中，将已知可诱导大鼠体重减轻的两种肿瘤细胞系之一植入SCID小鼠。Morris 7777肝癌的生长与体重减轻以及荷瘤小鼠脾细胞中肿瘤坏死因子和白细胞介素1和6水平的增加相关。MCA肉瘤的生长并没有引起体重减轻，也没有增加荷瘤小鼠脾细胞中细胞因子的表达。我们的结论是，增加细胞因子的表达与荷瘤SCID小鼠的体重减轻有关，细胞因子表达的免疫激活不需要T或B细胞的存在。(C)1997 Elsevier Science爱尔兰有限公司
It has been proposed that immunoregulatory cytokines play a role in the onset and development of cancer cachexia, although evidence supporting this theory remains inconclusive. In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. We conclude that increased cytokine expression is associated with weight loss in tumor-bearing SCID mice, and immune activation for cytokine expression does not require the presence of T or B cells. (C) 1997 Elsevier Science Ireland Ltd.