Gamiwalbitang, composed of four herbs, controls body weight increase and lipid level elevation induced by a high-fat diet in mice
Gamiwalbitang, composed of four herbs, controls body weight increase and lipid level elevation induced by a high-fat diet in mice
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DOI：
10.3109/08923970903335108
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Kim, Hyung-Min
中科院分区：
文献类型：
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作者：
An, Hyo-Jin;Rim, Hong-Kun;Kim, Hyung-Min
Gamiwalbitang（GWB）是一种新开发的膳食补充剂，由四种草药组成。GWB开发的目的是帮助控制体重。本研究的目的是调查GWB结合40%高脂（HF）饮食是否会影响体重和脂肪积累。用40只初始体重约为18 g的C57 BL/6 J小鼠进行实验。每周记录体重，并在研究结束时分析甘油三酯、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和瘦素的血浆水平。10%GWB组的体重增长比HF组低38.5%（P < 0.05）。与HF饮食组相比，5%GWB组的血浆甘油三酯和LDL胆固醇水平分别降低了21.2%和51.0%，10%GWB组分别降低了44.1%和51.5%。高密度脂蛋白胆固醇水平在5%GWB组和10%GWB组分别增加了184.0%和188.2%。GWB组血清瘦素水平显著低于HF组，且GWB组脂肪组织瘦素基因表达也低于HF组。这些结果表明，GWB可能是有益的高脂饮食诱导的血液循环障碍的调节。
Gamiwalbitang (GWB) is a newly developed dietary supplement that is composed of four herbs. The purpose of GWB development is to help control weight. The aim of this study was to investigate whether GWB combined with a 40% high-fat (HF) diet can influence body weight and fat accumulation. An experiment was conducted with 40 C57BL/6J mice with an initial body weight of approximately 18g. Body weight was recorded weekly, and plasma levels of triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and leptin were analyzed at the end of the study. Weight increases in the 10% GWB group were 38.5% less than in the HF diet group (P < 0.05). Plasma triglyceride and LDL cholesterol levels decreased by 21.2% and 51.0%, respectively, in the 5% GWB group, and 44.1% and 51.5%, respectively, in the 10% GWB group compared to the HF diet group. The HDL cholesterol level was increased by 184.0% in the 5% GWB group and 188.2% in the 10% GWB group. The serum leptin level was significantly decreased by the GWB diet, and in the GWB diet group; gene expression of leptin in adipose tissue was also decreased compared with HF diet group. These findings indicate that GWB may be beneficial in the regulation of high-fat diet-induced blood circulatory disorders.