Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes
Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes
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DOI：
10.1006/bbrc.2000.2598
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发表时间：
2000-04-29
影响因子：
3.1
通讯作者：
Theopold, U
中科院分区：
文献类型：
--
作者：
Fabbri, M;Delp, G;Theopold, U
在这里，我们描述了一个基因家族的新成员，具有相似的strictosidine synthase (SS)，在生产单萜吲哚生物碱的关键酶之一。除了先前描述的该家族的第一个动物成员（Drosophila hemomucin）外，还发现了第二个果蝇成员，其亚细胞分布似乎与hemomucin不同。在拟南芥中，ss样基因形成了一个多基因家族，可能具有抗食性和抗菌化合物的功能。在隐杆线虫中，已经确定了两个成员，小鼠和人类各有一个成员。有趣的是，人类类ss基因在大脑中强烈表达，而大脑正是许多吲哚类生物碱作用的器官。(C) 2000年学术出版社。
Here we describe novel members of a gene family which have similarity to strictosidine synthase (SS), one of the key enzymes in the production of monoterpene indole alkaloids. In addition to the first animal member of the family described previously (Drosophila hemomucin), a second Drosophila member has been identified, which appears to differ in subcellular distribution from hemomucin. In Arabidopsis, SS-like genes form a multigene family, compatible with a possible function as antifeedants and antibacterial compounds. In Caenorhabditis, two members have been identified and one member each in mouse and human. Interestingly, the human SS-like gene is strongly expressed in the brain, the very organ many of the indole alkaloids act upon. (C) 2000 Academic Press.