Predicting the behavior of microfluidic circuits made from discrete elements.
Predicting the behavior of microfluidic circuits made from discrete elements.
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DOI：
10.1038/srep15609
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发表时间：
2015-10-30
影响因子：
4.6
通讯作者：
Malmstadt N
中科院分区：
文献类型：
--
作者：
Bhargava KC;Thompson B;Iqbal D;Malmstadt N
微流体装置可用于以很高的精度执行各种连续流分析和合成化学方案。增材制造的日益增长的可用性使微流体装置的设计具有新的功能和复杂性。然而，这些装置倾向于比用微机械加工或软光刻制造的那些装置的典型制造变化更大的制造变化。在这份报告中，我们展示了一个设计制造工作流程，解决了在大规模制造和增材制造的背景下，在微流体元件和电路水平的性能变化。我们的方法依赖于离散的微流体元件，其特征在于其终端液压阻力和相关的公差。采用网络分析方法，为微流控回路模型建立了简单的解析设计规则。蒙特卡洛分析采用在单个元件和电路级，以建立预期的性能指标，为几个特定的电路配置。一个协议的基础上渗透压实验探测电路中的混合行为，以验证这些方法。整个工作流程应用于两个应用电路，可在工作台上立即使用：串联和并联混合电路，可模块化编程，几乎可预测，高度精确，可手动操作。
Microfluidic devices can be used to execute a variety of continuous flow analytical and synthetic chemistry protocols with a great degree of precision. The growing availability of additive manufacturing has enabled the design of microfluidic devices with new functionality and complexity. However, these devices are prone to larger manufacturing variation than is typical of those made with micromachining or soft lithography. In this report, we demonstrate a design-for-manufacturing workflow that addresses performance variation at the microfluidic element and circuit level, in context of mass-manufacturing and additive manufacturing. Our approach relies on discrete microfluidic elements that are characterized by their terminal hydraulic resistance and associated tolerance. Network analysis is employed to construct simple analytical design rules for model microfluidic circuits. Monte Carlo analysis is employed at both the individual element and circuit level to establish expected performance metrics for several specific circuit configurations. A protocol based on osmometry is used to experimentally probe mixing behavior in circuits in order to validate these approaches. The overall workflow is applied to two application circuits with immediate use at on the bench-top: series and parallel mixing circuits that are modularly programmable, virtually predictable, highly precise, and operable by hand.