A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.
A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.
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DOI：
10.1186/1756-8722-2-32
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发表时间：
2009-07-30
影响因子：
28.5
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Wang J;Lü S;Yang J;Song X;Chen L;Huang C;Hou J;Zhang W
老年急性髓系白血病(AML)患者对诱导缓解的反应仍然很差。本研究的目的是评价植物生物碱高三尖杉酯碱联合阿糖胞苷诱导治疗老年急性髓系白血病(≥)的疗效和毒性。23例患者接受HA方案治疗，其中高三尖杉酯碱2 mg/m2/d，连用7天；阿糖胞苷100 mg/m2/d，连用7天。总有效率56.5%，其中完全缓解(CR)39.1%，部分缓解(PR)17.4%。在这群患者中，没有人过早死亡。中位生存期(OS)为(12.0±3.0)个月。CR患者的OS时间估计为15个月。所有接受HA方案治疗的患者1年OS率估计为(49.3±13.5)%。CR患者1年OS率估计为(62.5±17.1)%。HA是一种适合于老年AML患者的诱导方案，毒性相对较低，有效率合理。
The response to remission induction in elderly patients with acute myeloid leukemia (AML) remains poor. The purpose of this paper is to evaluate the efficacy and toxicity of a plant alkaloid, homoharringtonine, in combination with cytarabine as an induction therapy for AML in elderly patients (≥60 years). Twenty-three patients were treated with the HA regimen consisting of homoharringtonine (2 mg/m2/day for 7 days) and cytarabine (Ara-C, 100 mg/m2/day for 7 days). The overall response rate was 56.5% with complete remission (CR) rate of 39.1% and partial remission of 17.4%. There was no early death in this cohort of patients. The estimated median overall survival (OS) time of all patients was (12.0 ± 3.0) months. The estimated OS time of the CR patients was 15 months. The estimated one-year OS rate of all patients treated with HA protocol was (49.3 ± 13.5) %. The estimated one-year OS rate of the CR patients was (62.5 ± 17.1) %. HA is a suitable induction regimen for elderly patients with AML, with relatively low toxicity and reasonable response rate.
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影响因子：
10.1
作者：
Pigneux, Arnaud;Perreau, Virginie;Reiffers, Josy
通讯作者：
Reiffers, Josy
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2.4
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影响因子：
11.4
作者：
Jin, J.;Jiang, D-Z;Xu, W-L
通讯作者：
Xu, W-L
影响因子：
2.7
作者：
Giles, FJ;Kantarjian, HM;Estey, E
通讯作者：
Estey, E
影响因子：
12.8
作者：
Lou, YJ;Jie, J;Tong, XM
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Tong, XM