STDP in the Developing Sensory Neocortex.
STDP in the Developing Sensory Neocortex.
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DOI：
10.3389/fnsyn.2010.00009
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发表时间：
2010-01-01
影响因子：
3.7
通讯作者：
Philpot, Benjamin D
中科院分区：
文献类型：
--
作者：
Larsen, Rylan S;Rao, Deepti;Philpot, Benjamin D
尖峰时间依赖可塑性（STDP）已被提出作为一种机制，用于优化神经元的调谐感觉输入，一个过程，形成感受野特性和联想记忆的基础。STDP的特性必须在发育过程中进行调整，以使神经元能够最佳地调整其对环境刺激的选择性，但这些变化知之甚少。在这里，我们回顾STDP的属性，以及如何在初级感觉皮质层2/3和4，皮质内处理的初始站点的发展过程中可能会发生变化。我们提供了一个引物讨论突触蛋白和神经调质，被认为是影响STDP的诱导和表达的出生后发育变化。我们建议，STDP的形状，但也修改，突触产生精细的神经元对感觉输入的反应。
Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental stimuli, but these changes are poorly understood. Here we review the properties of STDP and how these may change during development in primary sensory cortical layers 2/3 and 4, initial sites for intracortical processing. We provide a primer discussing postnatal developmental changes in synaptic proteins and neuromodulators that are thought to influence STDP induction and expression. We propose that STDP is shaped by, but also modifies, synapses to produce refinements in neuronal responses to sensory inputs.