EVALUATION OF DESFERAL AS A BIFUNCTIONAL CHELATING AGENT FOR LABELING ANTIBODIES WITH ZR-89
EVALUATION OF DESFERAL AS A BIFUNCTIONAL CHELATING AGENT FOR LABELING ANTIBODIES WITH ZR-89
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评估作为双功能螯合剂的去铁醛在用 Zr-89 标记抗体方面的作用
DOI：
10.1016/0883-2889(92)90170-j
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发表时间：
1992-12-01
影响因子：
1.6
通讯作者：
PINEDO, HM
中科院分区：
文献类型：
--
作者：
MEIJS, WE;HERSCHEID, JDM;PINEDO, HM
采用TLC、核磁共振、紫外可见光谱分析等手段对合成的二氢化锆进行了分析。络合物的化学计量比为1：1。在较宽的pH范围内(4-7)，在不同的缓冲体系中，脱氢表雄酮与树脂的络合速度很快，几乎是定量的。结果表明，所合成的锆络合物具有较高的体外稳定性，在血浆溶液中24小时内的失活量小于0.2%。
Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with Zr-88 appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.