The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study
The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study
复制标题
DOI：
10.1007/s10067-018-4151-x
复制
发表时间：
2018-10-01
影响因子：
3.4
通讯作者：
Raieskarimian, Farahnaz
中科院分区：
文献类型：
--
作者：
Rambod, Masoume;Nazarinia, Mohammadali;Raieskarimian, Farahnaz
目前还不清楚哪些种类和多少营养物质对类风湿关节炎的发展是有害的、预防的还是健康的。本研究旨在确定饮食习惯对类风湿关节炎发病机制的影响。本病例对照研究选取设拉子医科大学2015-2016年3家诊所的500例类风湿关节炎患者和500例健康对照者。病例组和对照组的数据采集均采用方便抽样。使用了一份经批准的、有效的、可靠的问卷，其中包括不同种类饮料的摄入量、营养和非营养饮食的信息。数据分析采用SPSS第20版，采用t检验、卡方和多元Logistic回归模型。类风湿关节炎的发展与以下变量之间的关联显著：每月喝1-7杯咖啡（OR = 0.44, CI = 0.25 - 0.76）、>= 8杯咖啡（OR = 0.50, CI = 0.28 - 0.90）、全脂牛奶（OR = 1.01, CI 1.003-1.03）、绿茶（OR = 0.65, CI 0.45 - 0.93）和固体油（OR = 2.29, CI:1.57-3.34）。根据研究结果，每月喝一杯以上的咖啡和绿茶可能对类风湿关节炎有预防作用。另一方面，每月摄入更多全脂牛奶和固体油的患者可能有患类风湿关节炎的风险。因此，建议在此基础上调整饮食。建议进行一项队列研究，以确定饮食习惯与类风湿关节炎的发展和预防之间的因果关系。
It has not been clear what kinds and how much nutrients could be harmful, preventive, or healthful for development of rheumatoid arthritis. This study aimed to determine the impact of dietary habits on the pathogenesis of rheumatoid arthritis. This case-control study was conducted on a total of 500 rheumatoid arthritis patients and 500 healthy controls refereed to three clinics of Shiraz University of Medical Sciences in 2015-2016. Convenience sampling was used for data collection in both case and control groups. An approved valid and reliable questionnaire including information about the intake of different kinds of beverages, and nutritious and non-nutritious diet was used. Data were analyzed by SPSS, version 20, using t test, chi-square and Multiple Logistic Regression model. The associations between rheumatoid arthritis development and variables including drinking 1-7 cups of coffee (OR = .44, CI .25-.76), >= 8 cups of coffee (OR = .50, CI .28-.90), full-fat milk (OR = 1.01, CI 1.003-1.03) per month, and intake of green tea (OR = .65, CI .45-.93) and solid oils (OR = 2.29, CI:1.57-3.34) were significant. Based on the findings, coffee consumption more than one cup per month and green tea might have preventive effects on developing rheumatoid arthritis. On the other hand, patients who consumed more full-fat milk per month and solid oil might be at risk of development of rheumatoid arthritis. Therefore, modification of diet based on these findings is suggested. Performing a cohort study to determine the causality effect of dietary habits and development and prevention of rheumatoid arthritis is recommended.