Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study
Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R Study
复制标题
DOI：
10.1183/09031936.00151010
复制
发表时间：
2012-03-01
影响因子：
24.3
通讯作者：
de Jongste, J. C.
中科院分区：
文献类型：
--
作者：
Gabriele, C.;Jaddoe, V. W.;de Jongste, J. C.
我们评估是否呼出一氧化氮分数（FeNO），嗜酸性粒细胞性气道炎症的标志物，在6个月与喘鸣的风险在头2年的life.In R世代出生队列，产前和产后的呼吸系统疾病和呼吸系统症状的危险因素进行了评估，在6个月和24个月的问卷调查。在428名婴儿中，在6个月的潮式呼吸期间成功测量了离线混合口/鼻FeNO。294名婴儿出生后6个月内的FeNO和呼吸道症状的完整数据可用。FeNO在男性中较高，与年龄呈正相关，与出生后6个月内的上呼吸道和下呼吸道症状呈负相关。Logistic回归分析显示，在6个月时测量的FeNO每增加ppb，婴儿在第二年的喘息风险增加1.06倍（95%置信区间1.01-1.11）。高FeNO（> 17.5 ppb）在预测第二年喘息中显示出有限的附加值。我们得出结论，6个月时的FeNO与喘息风险呈正相关，但在预测个别儿童第二年喘息中的附加值有限。
We assessed whether exhaled nitric oxide fraction (FeNO), a marker of eosinophilic airway inflammation, at 6 months was associated with the risk of wheezing during the first 2 yrs of life.In the Generation R birth cohort, pre- and post-natal risk factors for respiratory morbidity and respiratory symptoms were assessed by questionnaires at 6 and 24 months. In 428 infants, off-line mixed oral/nasal FeNO was successfully measured during tidal breathing at 6 months. Complete data on FeNO and respiratory symptoms within the first 6 months of life were available for 294 infants.FeNO was higher in males, was positively associated with age and was negatively associated with upper and lower respiratory symptoms within the first 6 months. Logistic regression analysis showed that for every ppb increase of FeNO measured at 6 months, infants had a 1.06 (95% confidence interval 1.01-1.11)-fold increased risk of wheezing in the second year of life. High FeNO (> 17.5 ppb) showed a limited added value in predicting wheezing in the second year.We conclude that FeNO at 6 months is positively associated with the risk of wheezing, but has limited added value in predicting wheezing in the second year of life in individual children.