Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia
Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia
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DOI：
10.1016/j.biopsych.2006.02.033
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发表时间：
2006-09-15
影响因子：
10.6
通讯作者：
Eyles, Darryl W.
中科院分区：
文献类型：
--
作者：
Kesby, James P.;Burne, Thomas H. J.;Eyles, Darryl W.
背景：发育性维生素D（DVD）缺乏被认为是精神分裂症的危险因素。短暂性产前维生素D缺乏的成年大鼠的行为表现为自发性过度运动，但声惊吓（PPI）的前脉冲抑制正常。本研究的目的是研究选定的精神药物和一个众所周知的抗精神病药物对DVD耗竭大鼠的行为表型的影响。方法：对照组与DVD耗竭成年大鼠在洞板，旷场和PPT在旷场进行了评估，动物给予MK-801和/或氟哌啶醇。结果：与对照组相比，DVD耗竭组大鼠在洞板任务中的运动量明显增加，MK-801对运动量的反应也明显增加。低剂量氟哌啶醇可优先拮抗DVD耗竭大鼠MK-801的过度活动，而高剂量氟哌啶醇可拮抗DVD耗竭大鼠MK-801的过度活动。在高剂量下，导致DVD消耗大鼠自发运动的更明显减少。DVD耗尽没有影响基线或药物介导的PPI respons.Conclusions：这些结果表明，DVD缺乏症与一个，持续改变与运动功能相关的神经元系统，但不与感觉运动门控。鉴于产前维生素D水平低与精神分裂症之间的假定关联。与DVD模型相关的离散行为差异可能有助于阐明精神分裂症的神经生物学相关性。
Background: Developmental vitamin D (DVD) deficiency has been proposed as a risk factor for schizophrenia. The behavioral phenotype of adult rats subjected to transient low prenatal vitamin D is characterized by spontaneous hyperlocomotion but normal prepulse inhibition of acoustic startle (PPI). The aim of this study was to examine the impact of selected psychotropic agents and one well-known antipsychotic agent on the behavioral phenotype of DVD deplete rats.Methods: Control versus DVD deplete adult rats were assessed on holeboard, openfield and PPT in the openfield, animals were given MK-801 and/or haloperidol. For PPI, the animals were given apomorphine cr MK-801.Results: DVD deplete rats bad increased baseline locomotion on the holeboard task and increased locomotion in response to MK-801 compared to control rats. At low doses, haloperidol antagonized the MK-801 hyperactivity of DVD deplete rats preferentially and. at a high dose, resulted in a more pronounced reduction in spontaneous locomotion in DVD deplete rats. DVD depletion did not affect either baseline or drug-mediated PPI response.Conclusions: These results suggest that DVD deficiency is associated with a,persistent alteration in neuronal systems associated with motor function but not those associated with sensory motor gating. In light of the putative association between low prenatal vitamin D and schizophrenia. the discrete behavioral differences associated with the DVD model may help elucidate the neurobiological correlates of schizophrenia.