Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson's disease
Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson's disease
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DOI：
10.1016/j.clineuro.2003.10.012
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发表时间：
2004-03-01
影响因子：
1.9
通讯作者：
Aral, M
中科院分区：
文献类型：
--
作者：
Dogu, O;Apaydin, D;Aral, M
目的：比较超声引导与非引导技术腮腺内注射 A 型肉毒毒素 (BTX-A) 治疗帕金森病 (PD) 患者流涎的疗效和安全性。方法：纳入15例PD伴流涎患者，分为两组。 A 组患者 (n = 8) 在超声引导下注射 BTX-A。 B 组患者 (n = 7) 在超声引导下注射 BTX-A。在基线以及第 1、4 和 12 周时对唾液分泌进行定量评估。患者和/或护理人员还使用视觉模拟量表 (VAS) 评估唾液分泌。结果：除一名患者外，所有患者均报告第一周流涎症状有改善。 A 组患者在第一周表现出显着更高的唾液减少率，而 B 组患者第一周唾液减少率与基线相比没有统计学意义（P > 0.05）。每次随访时对唾液定量评估的比较也表明，超声引导注射在减少唾液方面优于盲目注射。 VAS评分显示各组第一周的平均唾液分泌率有所改善（P < 0.05）。两名患者出现轻度口干症状，持续一个月。结论：超声引导下腮腺内注射 BTX-A 可能是治疗帕金森流涎的有效、简便且安全的方法。 (C) 2003 Elsevier B.V. 保留所有权利。
Objective: To investigate the efficacy and safety of intraparotid botulinum toxin-A (BTX-A) injections into parotid gland using ultrasoundguided versus nonguided techniques for the treatment of sialorrhoea in patients with Parkinson's disease (PD). Methods: 15 patients with PD and sialorrhoea were included and divided into two groups. Group A patients (n = 8) were injected with BTX-A using ultrasound guidance. Group B patients (n = 7) were injected with BTX-A without ultrasound guidance. Saliva secretion was assessed quantitatively at baseline and at weeks 1, 4, and 12. Patients and/or caregivers also assessed the saliva secretion using visual analog scale (VAS). Results: All patients except one reported subjective improvement in sialorrhoea at the first week. Group A patients showed significantly higher rate of saliva reduction at the first week, whereas in Group B the reduction was not statistically significant from baseline at the first week (P > 0.05). Comparisons of quantitative saliva assessments at each follow-up visit also showed that ultrasound-guided injections were superior to blind injections for saliva reduction. VAS scores showed an improvement in the mean rate of saliva secretion in each group at first week (P < 0.05). Two patients suffered from dry mouth in mild severity lasting I month. Conclusion: Intraparotid BTX-A injections using ultrasound guidance may be an effective, easy, and safe treatment for parkinsonian sialorrhoea. (C) 2003 Elsevier B.V. All rights reserved.