Multiple regions within 8q24 independently affect risk for prostate cancer
Multiple regions within 8q24 independently affect risk for prostate cancer
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DOI：
10.1038/ng2015
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发表时间：
2007-05-01
期刊：
影响因子：
30.8
通讯作者：
Reich, David
中科院分区：
文献类型：
--
作者：
Haiman, Christopher A.;Patterson, Nick;Reich, David
在最近发现8 q24中的常见遗传变异影响前列腺癌的遗传风险之后，我们对来自五个人群的多达7，518名患有和不患有前列腺癌的男性进行了2，973个SNP的基因分型。我们确定了7个风险变体，其中5个以前未描述过，跨越430 kb，每个独立预测前列腺癌的风险（P = 7.9 x 10（-19）的最强关联，P < 1.5 x 10（-4）的5个变体，在控制其他每个变体后）。这些变异定义了常见的基因型，在某些人群中，这些基因型对癌症的易感性范围超过五倍。没有一种前列腺癌风险变体与已知基因对齐或改变编码蛋白质的编码序列。
After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.