Scrapie pathogenesis in subclinically infected B-Cell-deficient mice
Scrapie pathogenesis in subclinically infected B-Cell-deficient mice
复制标题
DOI：
10.1128/jvi.73.11.9584-9588.1999
复制
发表时间：
1999-11-01
影响因子：
5.4
通讯作者：
Aguzzi, A
中科院分区：
文献类型：
--
作者：
Frigg, R;Klein, MA;Aguzzi, A
朊病毒感染可以没有临床表现。B细胞缺陷可能是亚临床传染性海绵状脑病的模型，因为它可以保护小鼠在腹腔内注射瘙痒症朊病毒后免受疾病的影响;然而，一部分B细胞缺陷小鼠的大脑中积累了蛋白酶抗性朊病毒蛋白。在这里，我们描述了这种亚临床疾病的特征。此外，我们还研究了B细胞分泌的神经毒性因子可能导致发病的可能性。
Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy, since it protects mice from disease upon intraperitoneal administration of scrapie prions; however, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains. Here, we have characterized this subclinical disease. In addition, we have studied the possibility that a neurotoxic factor secreted by B cells may contribute to pathogenesis.