Childhood outcomes of assisted reproductive technology
Childhood outcomes of assisted reproductive technology
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DOI：
10.1093/humrep/der212
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发表时间：
2011-09-01
影响因子：
6.1
通讯作者：
Cutfield, Wayne S.
中科院分区：
文献类型：
--
作者：
Savage, Tim;Peek, John;Cutfield, Wayne S.
通过辅助生殖技术（ART）怀孕的儿童人数众多，在世界范围内继续增加，但对相关的长期结果没有明确的了解。接受抗逆转录病毒疗法的儿童更有可能是多胎妊娠的结果，因此早产或出生体重低。越来越多的证据表明，ART儿童在表型和生化方面与自然受孕的儿童不同，但导致这些变化的机制尚未阐明。这些儿童患罕见印记基因疾病的风险可能会增加。然而，目前尚不清楚是否会发生更微妙的DNA甲基化变化，从而导致ART儿童的基因表达和表型差异。虽然有报道称ART儿童患癌症的风险增加，但ART在癌症发展中的作用尚未得到证实。对ART儿童的进一步研究和持续监测对于更好地了解ART对该人群长期健康的可能影响至关重要。
There is a large population of children conceived via assisted reproductive technology (ART), which continues to increase worldwide, without a clear understanding of associated long-term outcomes. ART children are more likely to be the result of multiple pregnancies, and thus to be born prematurely or low birthweight. There is growing evidence that ART children are phenotypically and biochemically different from naturally conceived children, but the mechanism(s) leading to these changes have not been elucidated. There is a possible increased risk of rare imprinted gene disorders in these children. However, it remains unclear whether more subtle changes in DNA methylation occur commonly, leading to differences in gene expression and phenotype in ART children. Although an increased risk of cancer among ART children has been reported, the role of ART in the development of cancer has not been demonstrated. Further research and ongoing surveillance of ART children is essential to better understand the possible effects of ART on the long-term health of this population.