Designs for phase I trials in ordered groups
Designs for phase I trials in ordered groups
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DOI：
10.1002/sim.7133
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发表时间：
2017-01-30
影响因子：
2
通讯作者：
Wages, Nolan A.
中科院分区：
文献类型：
--
作者：
Conaway, Mark R.;Wages, Nolan A.
我们提出了一种新的设计，剂量发现细胞毒性药物在两个有序组的患者。有序组是指在研究之前，有临床信息表明，对于给定剂量，一组患者比另一组患者更容易发生毒性。相对于两个先前提出的设计，在一系列的情况下随机产生的剂量-毒性曲线的顺序组的设计进行评估。版权所有（C）2016约翰威利父子有限公司
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose-toxicity curves. Copyright (C) 2016 John Wiley & Sons, Ltd.