The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism
The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism
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DOI：
10.1007/s40618-015-0262-2
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发表时间：
2016-06-01
影响因子：
5.4
通讯作者：
Kruzliak, P.
中科院分区：
文献类型：
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作者：
Shatynska-Mytsyk, I.;Rodrigo, L.;Kruzliak, P.
目的亚临床甲状腺功能减退症（SH）与老年人心力衰竭事件风险中度升高相关。我们的前瞻性研究的目的是评估低剂量左旋甲状腺素（6.25-25微克/天）的甲状腺激素替代治疗（HRT）对SH患者左心室舒张功能的影响。材料和方法涉及33名SH患者和25名健康对照。所有参与者在基线时和患者组在HRT一个疗程后均接受标准超声心动图和多普勒成像。（0.79 +/- 0.22 vs. 0.93 +/- 0.19，p < 0.001），E/A比值（1.19 +/- 0.29 vs. 1.31 +/- 0.25，p < 0.003），室间隔厚度（IVST）更高（0.99 +/- 0.14 vs. 0.89 +/- 0.18，p < 0.001）。治疗6个月后，E/A比值显著升高（1.28 +/- 0.21 vs. 1.19 +/- 0.29，p < 0.001），而IVS显示出稳健的降低结论HRT联合小剂量左旋甲状腺素可改善SH患者左室舒张功能。
Objective Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of l-thyroxine (6.25-25 mu g/day) on left ventricular diastolic function in patients with SH.Materials and methods 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT.Results At baseline, patients with SH showed significantly lower E (0.79 +/- 0.22 vs. 0.93 +/- 0.19, p < 0.001), E/A ratio (1.19 +/- 0.29 vs. 1.31 +/- 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 +/- 0.14 vs. 0.89 +/- 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 +/- 0.21 vs. 1.19 +/- 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 +/- 0.16 vs. 0.99 +/- 0.14, p < 0.001).Conclusions HRT with low-dosed l-thyroxine may improve left ventricular diastolic function in patients with SH.