Cognitive impairment after focal brain lesions is better predicted by damage to structural than functional network hubs
Cognitive impairment after focal brain lesions is better predicted by damage to structural than functional network hubs
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DOI：
10.1073/pnas.2018784118
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发表时间：
2021-05-11
影响因子：
11.1
通讯作者：
Boes, Aaron D.
中科院分区：
文献类型：
--
作者：
Reber, Justin;Hwang, Kai;Boes, Aaron D.
中枢是高度连接的大脑区域，对协调大脑网络中的处理非常重要。然而，目前尚不清楚哪种网络“中枢”测量方法在识别对人类认知至关重要的大脑区域方面最有用。在两组局灶性脑病变患者（N = 402和102，分别）中，我们使用跨越多个认知领域的认知测试，测试了两种测量方法——边缘密度和参与系数，分别来自白质和灰质——与脑损伤后的一般认知障碍之间的关系。破坏边缘密度高的白质区域的病变与认知障碍有关，而破坏参与系数高的灰质区域的病变与认知结果的关联较弱，不太一致。在其他六种灰质中心测量中也观察到了类似的结果。这表明，对密集连接的白质区域的损伤比对灰质中心的类似损伤更严重，这有助于解释脑损伤后认知结果的个体差异。
Hubs are highly connected brain regions important for coordinating processing in brain networks. It is unclear, however, which measures of network "hubness" are most useful in identifying brain regions critical to human cognition. We tested how closely two measures of hubness-edge density and participation coefficient, derived from white and gray matter, respectively-were associated with general cognitive impairment after brain damage in two large cohorts of patients with focal brain lesions (N = 402 and 102, respectively) using cognitive tests spanning multiple cognitive domains. Lesions disrupting white matter regions with high edge density were associated with cognitive impairment, whereas lesions damaging gray matter regions with high participation coefficient had a weaker, less consistent association with cognitive outcomes. Similar results were observed with six other gray matter hubness measures. This suggests that damage to densely connected white matter regions is more cognitively impairing than similar damage to gray matter hubs, helping to explain interindividual differences in cognitive outcomes after brain damage.