Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C-H Activation of Tethered Arenes
Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C-H Activation of Tethered Arenes
复制标题
N-酰基氨基酸配体在 Pd(II) 催化的束缚芳烃远程 C-H 活化中的作用
DOI：
10.1021/ja411683n
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发表时间：
2014-01-22
影响因子：
15
通讯作者：
Wu, Yun-Dong
中科院分区：
文献类型：
--
作者：
Cheng, Gui-Juan;Yang, Yun-Fang;Wu, Yun-Dong
对氨基酸配体辅助的钯催化的C-H键活化进行了实验和计算相结合的研究，揭示了氨基酸既是双阴离子双齿配体又是质子受体的机理。这个新的模型解释了氨基酸对反应活性和选择性的影响，并揭示了氨基酸的双重作用：稳定单体钯配合物和作为质子提取的内部碱。
A combined experimental/computational study on the amino acid ligand-assisted Pd-catalyzed C-H bond activation reveals a mechanism in which the amino acid acts as both a dianionic bidentate ligand and a proton acceptor. This new model explains the effects of amino acids on reactivity and selectivity and unveils the dual roles of amino acids: stabilizing monomeric Pd complexes and serving as the internal base for proton abstraction.