A solution to the 2-pyridyl organometallic cross-coupling problem:: Regioselective catalytic direct arylation of pyridine N-oxides
A solution to the 2-pyridyl organometallic cross-coupling problem:: Regioselective catalytic direct arylation of pyridine N-oxides
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DOI：
10.1021/ja056800x
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发表时间：
2005-12-28
影响因子：
15
通讯作者：
Fagnou, K
中科院分区：
文献类型：
--
作者：
Campeau, LC;Rousseaux, S;Fagnou, K
吡啶N-氧化物的直接芳基化反应以极高的产率发生，2-位与广泛的芳基溴化物具有完全的选择性。这种反应性允许在钯催化的交叉偶联反应中使用廉价的、商业上可获得的和工作台稳定的吡啶N-氧化物作为有问题的2-金属吡啶的替代品。
Direct arylation reactions of pyridineN-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridineN-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.