Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling
Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling
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DOI：
10.1128/mcb.01038-07
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发表时间：
2008-03-01
影响因子：
5.3
通讯作者：
Golden, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Cho, Ginam;Lim, Youngshin;Golden, Jeffrey A.
骨形态发生蛋白（BMPs）在神经系统发育过程中发挥着多营养作用，其信号传导几乎在神经系统发育的每一步都受到高度调控。我们克隆了一个新的基因，Sizn1 （smad相互作用锌指蛋白），它作为BMP信号的转录辅激活因子。它通过与Small家族成员相互作用并与转录复合体中的CBP相关，正向调节BNIP信号。Sizn1在胚胎前脑腹侧表达，在那里，正如我们将展示的，它有助于bmp依赖的，胆碱能神经元特异性基因表达。这些数据表明，Sizn1是BMP信号的正调节因子，并进一步深入了解BMP信号如何在神经元祖细胞亚群中被调节，从而影响细胞类型特异性基因的表达和发育。
Bone morphogenic proteins (BMPs) play pleotrophic roles in nervous system development, and their signaling is highly regulated at virtually every step in the pathway. We have cloned a novel gene, Sizn1 (Smad-interacting zinc finger protein), which functions as a transcriptional coactivator of BMP signaling. It positively modulates BNIP signaling by interacting with Small family members and associating with CBP in the transcription complex. Sizn1 is expressed in the ventral embryonic forebrain, where, as we will show, it contributes to BMP-dependent, cholinergic-neuron-specific gene expression. These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development.