Safety of ciprofloxacin in children with cystic fibrosis.
Safety of ciprofloxacin in children with cystic fibrosis.
复制标题
环丙沙星在囊性纤维化儿童中的安全性。
DOI：
10.1177/000992289303200811
复制
发表时间：
1993
影响因子：
1.6
通讯作者：
Yu,VL
中科院分区：
文献类型：
--
作者：
Orenstein,DM;Pattishall,EN;Noyes,BE;Kurland,G;Hartigan,ER;Yu,VL
异丙沙星是一种喹诺酮类抗生素，对大多数铜绿假单胞菌有抗菌活性。由于该药物即使口服也有效，因此环丙沙星作为治疗囊性纤维化患者肺部加重的有用工具最近受到关注。1-3然而，它在囊性纤维化中的应用受到了儿童关节毒性的限制，这显然是由于服用喹诺酮类药物的幼年动物承重关节软骨侵蚀的报道。在服用环丙沙星的一些患者中也报告了间质性肾炎。L
Introduction iprofloxacin, a quinolone~ antibiotic, is active against most strains of Pseudo-monas aeruginosa. Because the drug is effective even when administered orally, ciprofloxacin has gained recent attention as a useful tool in the treatment of pulmonary exacerbations in patients with cystic fibrosis. 1-3 Its use in cystic fibro-sis, however, has been limited by fears of possible joint toxicity in children, apparently prompted by reports of the erosion of cartilage in weight-bearing joints of imma-ture animals given quinolones.~ In-terstitial nephritis has also been reported in some patients taking ciprofloxacin. l