Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma
复制标题
脂联素水平降低与舌鳞状细胞癌的侵袭性表型相关
DOI：
10.1111/cas.12077
复制
发表时间：
2013-02-01
期刊：
影响因子：
5.7
通讯作者：
Wu, Li-Ling
中科院分区：
文献类型：
--
作者：
Guo, Xiao-Hong;Wang, Jin-Yu;Wu, Li-Ling
循环脂联素水平与各种肥胖相关癌症的风险呈负相关。然而，脂联素在舌鳞状细胞癌（TSCC）发生发展中的作用尚不清楚。我们检测了59例TSCC患者和50例健康对照者的血清脂联素水平。分别采用免疫组化法（n=37）和western blot法（n=30）检测配对的癌组织和癌旁组织中脂联素及其受体的表达。患者血清脂联素水平低于对照组（5.0 ± 2.4 vs 8.4 ± 3.5g/mL，P
Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n=37) and western blot (n=30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 +/- 2.4 vs 8.4 +/- 3.5g/mL, P