Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis.
Intestinal Epithelial Barrier Function and Necrotizing Enterocolitis.
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DOI：
10.5005/jp-journals-11002-0003
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
De Plaen, Isabelle G
中科院分区：
文献类型：
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作者：
Managlia, Elizabeth;Yan, Xiaocai;De Plaen, Isabelle G
坏死性小肠结肠炎（NEC）是早产儿发病和死亡的主要原因。NEC的特征在于肠组织炎症和坏死。NEC患者肠道屏障改变，可能通过促进肠道细菌移位和刺激炎症反应而导致其发病。在早产儿中，肠屏障的许多成分是不成熟的。本文综述了肠屏障的不同组成部分，以及它们的不成熟如何导致肠屏障功能障碍和NEC。
Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. NEC is characterized by intestinal tissue inflammation and necrosis. The intestinal barrier is altered in NEC, which potentially contributes to its pathogenesis by promoting intestinal bacterial translocation and stimulating the inflammatory response. In premature infants, many components of the intestinal barrier are immature. This article reviews the different components of the intestinal barrier and how their immaturity contributes to intestinal barrier dysfunction and NEC.