Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
复制标题
DOI：
10.1002/ajmg.b.10001
复制
发表时间：
2003-01-01
影响因子：
2.8
通讯作者：
Cohen, DJ
中科院分区：
文献类型：
--
作者：
Leckman, JF;Pauls, DL;Cohen, DJ
强迫症（OCD）是一种病因异质性疾病。近期的因素分析一致确定了几个症状维度，其中两个与强迫症的家族风险增加有关；攻击性、性和宗教方面的强迫观念以及检查强迫行为（因素1）和对称与排序方面的强迫观念以及强迫行为（因素2）。这两个症状维度在吉尔·德拉·图雷特综合征（GTS）中也经常出现。本研究的目的是确定这些强迫症状维度在家庭内部（兄弟姐妹之间以及亲子对之间）是否相关。利用由图雷特综合征国际遗传学关联同胞对研究协会收集的数据，作者选取了所有可获取的GTS同胞对及其父母，这些人的这些强迫症状维度（因子得分）能够生成。该组包括128对全同胞及其母亲（54人）和父亲（54人）。使用从耶鲁 - 布朗强迫症量表（Y - BOCS）症状检查表的项目认可中得出的算法，为每个家庭成员计算四个强迫症状维度得分。除了一系列单变量分析外，还使用这些定量的强迫症状维度得分完成了复杂的分离分析。在GTS一致的同胞对中，因素1和因素2得分显著相关。对于这两个因素，母子相关性显著，但父子相关性不显著。分离分析与因素1和因素2的显性主基因效应一致。我们得出结论，家族因素对GTS家庭中的强迫症状维度表型有显著影响。这种家族影响可能是遗传的或环境的。（C）2003威利 - 利斯公司
Obsessive-compulsive disorder (OCD) is an etiologically heterogeneous disorder. Recent factor analyses have consistently identified several symptom dimensions, two of which are associated with increased familial risk for OCD; aggressive, sexual, and religious obsessions and checking compulsions (FACTOR 1) and symmetry and ordering obsessions and compulsions (FACTOR 2). Both of these symptom dimensions are also frequently seen in association with Gilles de la Tourette syndrome (GTS). The purpose of this study was to determine whether these obsessive-compulsive (OC) symptom dimensions are correlated within families (between sibs and between parent-child pairs). Using data collected by the Tourette Syndrome Association International Consortium for Genetics Affected Sibling Pair Study, the authors selected all available GTS sib pairs and their parents for which these OC symptom dimensions (factor scores) could be generated. This group included 128 full sibs and their mothers (54) and fathers (54). Four OC symptom dimension scores were computed for each family member using an algorithm derived from item endorsements from the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) symptom checklist. In addition to a series of univariate analyses, complex segregation analyses were also completed using these quantitative OC symptom dimension scores. FACTOR 1 and FACTOR 2 scores were significantly correlated in sib pairs concordant for GTS. The mother-child correlations, but not father-child correlations, were also significant for these two factors. Segregation analyses were consistent with dominant major gene effects for both FACTOR 1 and FACTOR 2. We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental. (C) 2003 Wiley-Liss, Inc.