Diversified Cycloisomerization/Diels-Alder Reactions of 1,6-Enynes through Bimetallic Relay Asymmetric Catalysis
Diversified Cycloisomerization/Diels-Alder Reactions of 1,6-Enynes through Bimetallic Relay Asymmetric Catalysis
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通过双金属继电器不对称催化实现 1,6-烯炔的多样化环异构化/Diels-Alder 反应
DOI：
10.1002/anie.201900421
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Xiaoming Feng
中科院分区：
文献类型：
--
作者：
Haifeng Zheng;Yan Wang;Chaoran Xu;Qian Xiong;Lili Lin;Xiaoming Feng
我们报道了过渡金属催化的1，6-烯炔的多种环异构化反应与手性刘易斯酸促进的不对称Diels-Alder反应相结合，实现了1，6-烯炔与缺电子烯烃的不对称环异构化/Diels-Alder接力反应.可以以高收率（高达99%）获得广谱的手性[5，6]-双环产物，具有优异的非对映选择性（>19：1 dr）和对映选择性（高达99%ee）。
We report the combination of transition‐metal‐catalyzed diversified cycloisomerization of 1,6‐enynes with chiral Lewis acid promoted asymmetric Diels–Alder reaction to realize asymmetric cycloisomerization/Diels–Alder relay reactions of 1,6‐enynes with electron‐deficient alkenes. A broad spectrum of chiral [5,6]‐bicyclic products could be acquired in high yields (up to 99 %) with excellent diastereoselectivy (>19:1 dr) and enantioselectivity (up to 99 %ee).