Control of the yeast cell cycle by the Cdc28 protein kinase
Control of the yeast cell cycle by the Cdc28 protein kinase
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DOI：
10.1016/0955-0674(93)90099-c
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发表时间：
1993-04-01
影响因子：
7.5
通讯作者：
Nasmyth, Kim
中科院分区：
文献类型：
--
作者：
Nasmyth, Kim
越来越明显的是，Cdc 28在酵母细胞周期中的不同功能是由以其细胞周期蛋白亚基为特征的激酶形式来执行的。在START进入细胞周期涉及Cln细胞周期蛋白。5期需要Clb 5或Clb 6 B型细胞周期蛋白。双极有丝分裂纺锤体的形成涉及Clb 1 -4 B型细胞周期蛋白。许多细胞周期事件的顺序和时间可能涉及Cdc 28激酶活性的逐步激活与不同的细胞周期蛋白，其周期在周期期间是由转录和转录后控制。
It is becoming increasingly apparent that the diverse functions of Cdc28 during the yeast cell cycle are performed by forms of the kinase that are distinguished by their cyclin subunits. Entry into the cell cycle at START involves the Cln cyclins. 5 phase needs Clb5 or Clb6 B-type cyclins. Bipolar mitotic spindle formation involves Clb1-4 B-type cyclins. Much of the order and timing of the cell cycle events may involve the progressive activation of Cdc28 kinase activities associated with different cyclins, whose periodicity during the cycle is determined by both transcriptional and post-transcriptional controls.