The systemic nature of mustard lung: Comparison with COPD patients.
The systemic nature of mustard lung: Comparison with COPD patients.
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DOI：
10.1515/intox-2017-0018
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发表时间：
2017-11
影响因子：
--
通讯作者：
Rahmani H
中科院分区：
文献类型：
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作者：
Shahriary A;Ghanei M;Rahmani H
硫磺芥子气（SM）是一种强效的引起水泡的烷基化化学战剂，伊拉克军队使用它来对付伊朗。芥子气吸入的已知并发症之一是芥子气肺，这是慢性阻塞性肺疾病（COPD）的一种表型。在这种并发症中，有临床症状接近慢性阻塞性肺病与常见的病因，如吸烟者。根据对芥子气肺患者的研究逐渐获得的信息，全身症状和肺部疾病引起了研究人员的注意。血清炎症标志物，如c反应蛋白（CRP）、肿瘤坏死因子α (TNF-α)、核因子κB （NF-κB）、基质金属蛋白酶（MMPs）、白细胞介素（IL）、趋化因子、选择素、免疫球蛋白等水平的变化，以及血清氧化-抗氧化系统失衡的迹象，呈现出这些患者的全体性变化。除此之外，还报道了肺外并发症，如骨质疏松症和心血管疾病。本研究通过对比研究上述指标在芥菜肺和COPD患者稳定期的变化，以及这些患者气道重塑等发病机制和现象，来追踪该肺部疾病发生全身性的机会。
Sulphur mustard (SM) is a powerful blister-causing alkylating chemical warfare agent used by Iraqi forces against Iran. One of the known complications of mustard gas inhalation is mustard lung which is discussed as a phenotype of chronic obstructive pulmonary disease (COPD). In this complication, there are clinical symptoms close to COPD with common etiologies, such as in smokers. Based on information gradually obtained by conducting the studies on mustard lung patients, systemic symptoms along with pulmonary disorders have attracted the attention of researchers. Changes in serum levels of inflammatory markers, such as C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), nuclear factor κB (NF-κB), matrix metalloproteinases (MMPs), interleukin (IL), chemokines, selectins, immunoglobulins, and signs of imbalance in oxidant-antioxidant system at serum level, present the systemic changes in these patients. In addition to these, reports of extra-pulmonary complications, such as osteoporosis and cardiovascular disease are also presented. In this study, the chance of developing the systemic nature of this lung disease have been followed on using the comparative study of changes in the mentioned markers in mustard lung and COPD patients at stable phases and the mechanisms of pathogenesis and phenomena, such as airway remodeling in these patients.