Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold
Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold
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DOI：
10.1016/j.resp.2006.08.009
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发表时间：
2007-05-14
影响因子：
2.3
通讯作者：
Mookerjee, Swapan
中科院分区：
文献类型：
--
作者：
Bhambhani, Yagesh;Malik, Rohit;Mookerjee, Swapan
在渐进式运动中，PaCO2和PETCO2在呼吸代偿阈值处开始下降（RCT-GEX）。由于Paco改变了脑血流量，因此假设近红外光谱测量的脑氧合（Cox）高于RCT （RCT- nirs）会有系统性下降。在17名男性的增量运动过程中，从左额叶同时监测心肺和近红外反应。所有受试者的Cox均在RCTLGEX以上下降，并有20-40 s的延迟。RCT-GEX和RCT-NIRS在时间（9.83 vs 10.39 min）、功率（198 vs 212 W）和摄氧量（2.31 vs 2.43 L min(-1)）方面存在显著差异（P < 0.01）。功率和绝对VO2的类内相关性分别为0.97和0.98。布兰德-奥特曼分析显示，任何变量都没有异常值。结果表明，在RCT上观察到的Cox -皱纹很可能是由于Paco下降引起的脑血流量减少，这种Cox下降可以减少神经元激活，从而限制健康受试者的最大运动能力。(c) 2006 Elsevier B.V.版权所有
During incremental exercise PaCO2 and PETCO2 begin to decline at the respiratory compensation threshold (RCT-GEX). Since Paco, alters cerebral blood flow it was hypothesized that there would be a systematic decline in cerebral oxygenation (Cox) measured by near infrared spectroscopy above the RCT (RCT-NIRS). Cardiorespiratory and NIRS responses were simultaneously monitored from the left frontal lobe during incremental exercise in 17 men. All subjects showed a decline in Cox above the RCTLGEX with a 20-40 s delay. Significant differences (P < 0.01) were observed between the RCT-GEX and RCT-NIRS for time (9.83 versus 10.39 min), power (198 versus 212 W) and oxygen uptake (2.31 versus 2.43 L min(-1)). Intra-class correlations for power and absolute VO2 were 0.97 and 0.98, respectively. Bland-Altman analysis revealed no outliers for any of the variables. The results suggested that the &-crease in Cox observed above the RCT was most likely due to a reduction in cerebral blood flow mediated by a decline in Paco, This decline in Cox could reduce neuronal activation thereby limiting maximal exercise capacity in healthy subjects. (c) 2006 Elsevier B.V. All rights reserved.