Menstrual patterns and risk of adult-onset diabetes mellitus
Menstrual patterns and risk of adult-onset diabetes mellitus
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DOI：
10.1016/s0895-4356(00)00240-7
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发表时间：
2000-11-01
影响因子：
7.2
通讯作者：
Sandler, DP
中科院分区：
文献类型：
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作者：
Cooper, GS;Ephross, SA;Sandler, DP
我们对 668 名受过大学教育的白人女性进行了一项前瞻性研究，研究了月经模式与患成人糖尿病的风险之间的关联，这些女性在整个育龄期间都完成了月经日记。我们计算了年龄小于或等于 22 岁、23-27 岁、28-32 岁和 33-37 岁的周期长度和变异性以及出血持续时间的汇总测量值。该分析包括 35,418 人年的随访和 49 例自我报告的糖尿病病例（诊断时的中位年龄为 63 岁）。糖尿病风险与初潮年龄、平均周期长度、周期变异性或长周期频率（> 42 天）之间没有关联。生育中期和晚期的较长出血期在一定程度上与糖尿病风险增加有关（调整后的比率为 1.4，95% 置信区间为 28-32 岁期间月经出血持续时间每天增加 1.0-1.8）。这些结果并不支持月经周期长或不规则与绝经后糖尿病发病率之间的关联，但确实表明较长的出血持续时间与随后的糖尿病发病可能存在关联。 (C) 2000 Elsevier Science Inc. 保留所有权利。
We examined the association between menstrual patterns and risk of developing adult-onset diabetes in a prospective study of 668 white, college-educated women who completed menstrual diaries throughout their reproductive years. We calculated summary measures of cycle length and variability and bleeding duration for ages less than or equal to 22, 23-27, 28-32, and 33-37 years. The analysis included 35,418 person-years of follow-up and 49 self-reported cases of diabetes (median age at diagnosis, 63 years). There was no association between diabetes risk and age at menarche, mean cycle length, cycle variability, or frequency of long cycles (>42 days). Longer bleeding periods in the mid- and late reproductive years were somewhat associated with an increased risk of diabetes (adjusted rate ratio 1.4, 95% confidence interval 1.0-1.8 per day increase in bleeding duration for menses during ages 28-32). These results do not support the association of long or irregular menstrual cycles with post-menopausal diabetes incidence, but do suggest a possible association of longer bleeding duration with subsequent onset of diabetes. (C) 2000 Elsevier Science Inc. All rights reserved.