Whole-Genome Sequences of Two Borrelia afzelii and Two Borrelia garinii Lyme Disease Agent Isolates
Whole-Genome Sequences of Two Borrelia afzelii and Two Borrelia garinii Lyme Disease Agent Isolates
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DOI：
10.1128/jb.05951-11
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发表时间：
2011-12-01
影响因子：
3.2
通讯作者：
Schutzer, Steve E.
中科院分区：
文献类型：
--
作者：
Casjens, Sherwood R.;Mongodin, Emmanuel F.;Schutzer, Steve E.
人类莱姆病通常由疏螺旋体属中的几种螺旋体引起。在欧亚大陆，这些物种主要是阿氏疏螺旋体，B。garinii，B. burgdorferi和B.全基因组测序是研究和理解细菌多样性对莱姆病发病机制和病因学的影响的极好工具。我们在这里报告的全基因组序列的四个分离的两个疏螺旋体物种，导致人类莱姆病，B。afzelii分离ACA-1、PKo和B。Garinii分离物PBr和Far 04。
Human Lyme disease is commonly caused by several species of spirochetes in the Borrelia genus. In Eurasia these species are largely Borrelia afzelii, B. garinii, B. burgdorferi, and B. bavariensis sp. nov. Whole-genome sequencing is an excellent tool for investigating and understanding the influence of bacterial diversity on the pathogenesis and etiology of Lyme disease. We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04.