Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance
Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance
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DOI：
10.1002/jbm.a.36880
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发表时间：
2020-01-20
影响因子：
4.9
通讯作者：
Khor, Khiam Aik
中科院分区：
文献类型：
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作者：
Li, Zhong;Zhu, Wenyu;Khor, Khiam Aik
各种生物活性陶瓷如羟基磷灰石（HA）在骨科中的应用受到其力学性能不足，特别是断裂韧性差的限制。因此，进一步扩大这些材料的临床应用需要提高其力学性能。虽然2D纳米材料对陶瓷的增强作用已经得到了很好的认可，但在设计和合成这种复合材料时，忽略了结构、机械和功能方面的综合考虑。在本文中，我们报告了第一次使用二氧化硅涂覆的还原氧化石墨烯（S-rGO）混合纳米片来创建同时增强机械和生物性能的生物陶瓷基复合材料。在通过放电等离子体烧结制备的代表性HA基生物陶瓷系统中，发现S-rGO掺入比未涂覆的还原GO（rGO）的掺入更有效地增加杨氏模量、硬度和断裂韧性。此外，当使用成骨细胞样MG-63细胞进行评估时，此类新型材料比纯HA通常观察到的细胞增殖更快、细胞活力和碱性磷酸酶活性更高;此外，细胞对S-rGO/HA的亲和力比对rGO/HA的亲和力更强HA复合材料。因此，S-rGO/生物陶瓷复合材料在骨科组织工程中的应用是有前途的，这项研究为二氧化硅涂层的混合纳米片增强陶瓷的制造提供了有价值的见解。
The applications of a variety of bioactive ceramics such as hydroxyapatite (HA) in orthopedics are limited by their insufficient mechanical properties, especially poor fracture toughness. Thus, further extending the clinical applications of these materials warrants the enhancement of their mechanical properties. Although the reinforcement of ceramics by 2D nanomaterials has been well recognized, integrated structural, mechanical, and functional considerations have been neglected in the design and synthesis of such composite materials. Herein, we report the first use of silica-coated reduced graphene oxide (S-rGO) hybrid nanosheets to create bioceramic-based composites with simultaneously enhanced mechanical and biological properties. In the representative HA-based bioceramic systems prepared by spark plasma sintering, S-rGO incorporation was found to be more effective for increasing the Young's modulus, hardness, and fracture toughness than the incorporation of uncoated reduced GO (rGO). Furthermore, when assessed with osteoblast-like MG-63 cells, such novel materials led to faster cell proliferation and higher cell viability and alkaline phosphatase activity than are generally observed with pure HA; additionally, cells demonstrate stronger affinity to S-rGO/HA than to rGO/HA composites. The S-rGO/bioceramic composites are therefore promising for applications in orthopedic tissue engineering, and this research provides valuable insights into the fabrication of silica-coated hybrid nanosheet-reinforced ceramics.